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  A humanised rat model reveals ultrastructural differences between bone and mineralised tumour tissue

Lahr, C. A., Landgraf, M., Wagner, F., Cipitria, A., Moreno-Jiménez, I., Bas, O., et al. (2022). A humanised rat model reveals ultrastructural differences between bone and mineralised tumour tissue. Bone, 158: 116018. doi:10.1016/j.bone.2021.116018.

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 Urheber:
Lahr, Christoph A., Autor
Landgraf, Marietta, Autor
Wagner, Ferdinand, Autor
Cipitria, Amaia1, Autor                 
Moreno-Jiménez, Inés1, Autor           
Bas, Onur, Autor
Schmutz, Beat, Autor
Meinert, Christoph, Autor
Mashimo, Tomoji, Autor
Miyasaka, Yoshiki, Autor
Holzapfel, Boris M., Autor
Shafiee, Abbas, Autor
McGovern, Jacqui A., Autor
Hutmacher, Dietmar W., Autor
Affiliations:
1Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2489692              

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Schlagwörter: Bone, Tumour, Osteosarcoma, Ultrastructure, Collagen, Animal model, Orthotopic bone model, Tissue humanisation, Humanised animal model, Rat model
 Zusammenfassung: Current xenograft animal models fail to accurately replicate the complexity of human bone disease. To gain translatable and clinically valuable data from animal models, new in vivo models need to be developed that mimic pivotal aspects of human bone physiology as well as its diseased state. Above all, an advanced bone disease model should promote the development of new treatment strategies and facilitate the conduction of common clinical interventional procedures. Here we describe the development and characterisation of an orthotopic humanised tissue-engineered osteosarcoma (OS) model in a recently genetically engineered x-linked severe combined immunodeficient (X-SCID) rat. For the first time in a genetically modified rat, our results show the successful implementation of an orthotopic humanised tissue-engineered bone niche supporting the growth of a human OS cell line including its metastatic spread to the lung. Moreover, we studied the inter- and intraspecies differences in ultrastructural composition of bone and calcified tissue produced by the tumour, pointing to the crucial role of humanised animal models.

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Sprache(n): eng - English
 Datum: 2021-05-202022
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1016/j.bone.2021.116018
BibTex Citekey: LAHR2021116018
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Titel: Bone
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York : Elsevier
Seiten: - Band / Heft: 158 Artikelnummer: 116018 Start- / Endseite: - Identifikator: ISSN: 8756-3282