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  A humanised rat model reveals ultrastructural differences between bone and mineralised tumour tissue

Lahr, C. A., Landgraf, M., Wagner, F., Cipitria, A., Moreno-Jiménez, I., Bas, O., et al. (2022). A humanised rat model reveals ultrastructural differences between bone and mineralised tumour tissue. Bone, 158: 116018. doi:10.1016/j.bone.2021.116018.

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 Creators:
Lahr, Christoph A., Author
Landgraf, Marietta, Author
Wagner, Ferdinand, Author
Cipitria, Amaia1, Author              
Moreno-Jiménez, Inés1, Author              
Bas, Onur, Author
Schmutz, Beat, Author
Meinert, Christoph, Author
Mashimo, Tomoji, Author
Miyasaka, Yoshiki, Author
Holzapfel, Boris M., Author
Shafiee, Abbas, Author
McGovern, Jacqui A., Author
Hutmacher, Dietmar W., Author
Affiliations:
1Amaia Cipitria, Biomaterialien, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2489692              

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Free keywords: Bone, Tumour, Osteosarcoma, Ultrastructure, Collagen, Animal model, Orthotopic bone model, Tissue humanisation, Humanised animal model, Rat model
 Abstract: Current xenograft animal models fail to accurately replicate the complexity of human bone disease. To gain translatable and clinically valuable data from animal models, new in vivo models need to be developed that mimic pivotal aspects of human bone physiology as well as its diseased state. Above all, an advanced bone disease model should promote the development of new treatment strategies and facilitate the conduction of common clinical interventional procedures. Here we describe the development and characterisation of an orthotopic humanised tissue-engineered osteosarcoma (OS) model in a recently genetically engineered x-linked severe combined immunodeficient (X-SCID) rat. For the first time in a genetically modified rat, our results show the successful implementation of an orthotopic humanised tissue-engineered bone niche supporting the growth of a human OS cell line including its metastatic spread to the lung. Moreover, we studied the inter- and intraspecies differences in ultrastructural composition of bone and calcified tissue produced by the tumour, pointing to the crucial role of humanised animal models.

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Language(s): eng - English
 Dates: 2021-05-202022
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.bone.2021.116018
BibTex Citekey: LAHR2021116018
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Title: Bone
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 158 Sequence Number: 116018 Start / End Page: - Identifier: ISSN: 8756-3282