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  An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence

Aukland, M. H., Talbot, F. J. T., Fernández-Salas, J. A., Ball, M., Pulis, A. P., & Procter, D. J. (2018). An Interrupted Pummerer/Nickel-Catalysed Cross-Coupling Sequence. Angewandte Chemie International Edition, 57(31), 9785-9789. doi:10.1002/anie.201805396.

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 Creators:
Aukland, Miles H.1, Author              
Talbot, Fabien J. T.1, Author
Fernández-Salas, José A. 1, Author
Ball, Matthew2, Author
Pulis, Alexander P.1, Author
Procter, David J.1, Author
Affiliations:
1Department of Chemistry, University of Manchester, Manchester, UK, ou_persistent22              
2Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA UK, ou_persistent22              

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Free keywords: cross-coupling; nickel catalysis; Pummerer reactions; sulfonium salts; sulfoxides
 Abstract: An interrupted Pummerer/nickel-catalysed cross-coupling strategy has been developed and used in the elaboration of styrenes. The operationally simple method can be carried out as a one-pot process, involves the direct formation of stable alkenyl sulfonium salt intermediates, utilises a commercially available sulfoxide, catalyst, and ligand, operates at ambient temperature, accommodates sp-, sp2-, and sp3-hybridised organozinc coupling partners, and delivers functionalised styrene products in high yields over two steps. An interrupted Pummerer/cyclisation approach has also been used to access carbo- and heterocyclic alkenyl sulfonium salts for cross-coupling.

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Language(s): eng - English
 Dates: 2018-05-092018-06-082018-07-26
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201805396
 Degree: -

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Title: Angewandte Chemie International Edition
  Abbreviation : Angew. Chem., Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 57 (31) Sequence Number: - Start / End Page: 9785 - 9789 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851