English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization

Reutzel, D., Mende, M., Naumann, S., Störkel, S., Brenner, W., Zabel, B., et al. (2001). Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization. Cytogenetics and Genome Research, 93(3-4), 221-227. doi:10.1159/000056987.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Reutzel, D., Author
Mende, Michael1, Author           
Naumann, S., Author
Störkel, S., Author
Brenner, W., Author
Zabel, B., Author
Decker, J., Author
Affiliations:
1ou_persistent22, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Comparative genomic hybridization (CGH) has been applied to characterize 61 primary renal cell carcinomas derived histogenetically from the proximal tubulus. The tumor samples comprised 46 clear-cell renal cell carcinomas (ccRCCs) and 15 papillary renal cell carcinomas (pRCCs). Changes in the copy number of entire chromosomes or subregions were detected in 56 tumors (92%). In ccRCCs, losses of chromosome 3 or 3p (63%); 14q (30%); 9 (26%); 1 and 6 or 6q (17% each); 4 and 8 or 8p (15% each); 22 (11%); 2 or 2q and 19 (9% each); 7q, 10, 16, 17p, 18, and Y (7% each); and 5, 11, 13, 15, and 21 (4% each) were detected. Most frequent genomic gains in ccRCC were found on chromosome 5 (63%); 7 (35%); 1 or 1q (33%); 2q (24%); 8 or 8q, 12, and 20 (20% each); 3q (17%); 16 (15%); 19 (13%); 6 and 17 or 17q (11% each); and 4, 10, 11, 21, and Y (9% each). In pRCCs, gains in the copy number of chromosomes 7 and 17 (7/15, each) and 16 and 20 (6/15, each) were frequent. One pRCC showed amplification of subchromosome regions 2q22→q33, 16q, 17q and the entire X chromosome. In pRCC, losses were less frequently seen than gains. Losses of chromosomes 1, 14, 15, and Y (3/15 each) and 2, 4, 6, and 13 (2/15 each) were observed. In ccRCCs, statistical evaluation revealed significant correlations of chromosomal imbalances with tumor stage and grade, i.e., a gain in copy number of chromosome 5 correlated positively with low tumor grade, whereas a gain of chromosomes 10 and 17 correlated positively with high tumor grade. Furthermore, loss of chromosome 4 correlated positively with high tumor stage.   

Details

show
hide
Language(s):
 Dates: 2001-01-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1159/000056987
ISSN: 1424-8581
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cytogenetics and Genome Research
  Other : Cytogenet Genome Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Basel : S. Karger.
Pages: - Volume / Issue: 93 (3-4) Sequence Number: - Start / End Page: 221 - 227 Identifier: ISSN: 0301-0171
CoNE: https://pure.mpg.de/cone/journals/resource/111006469463154