Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Melatonin promotes regeneration of injured motor axons via MT1 receptors.

Stazi, M., Negro, S., Megighian, A., D'Este, G., Solimena, M., Jockers, R., et al. (2020). Melatonin promotes regeneration of injured motor axons via MT1 receptors. Journal of pineal research, 70(1): e12695. doi:10.1111/jpi.12695.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Stazi, Marco, Autor
Negro, Samuele, Autor
Megighian, Aram, Autor
D'Este, Giorgia, Autor
Solimena, Michele1, Autor           
Jockers, Ralf, Autor
Lista, Florigio, Autor
Montecucco, Cesare, Autor
Rigoni, Michela, Autor
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Melatonin is an ancient multi-tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different physiological and pathological contexts, but little is known about its role in peripheral neuroregeneration. Here, we have exploited two different types of injury to test the capability of melatonin to stimulate regeneration of motor axons: (a) the acute and reversible presynaptic degeneration induced by the spider neurotoxin α-Latrotoxin and (b) the compression/transection of the sciatic nerve. We found that in both cases melatonin administration accelerates the process of nerve repair. This pro-regenerative action is MT1 -mediated, and at least in part due to a sustained activation of the ERK1/2 pathway. These findings reveal a receptor-mediated, pro-regenerative action of melatonin in vivo that holds important clinical implications, as it posits melatonin as a safe candidate molecule for the treatment of a number of peripheral neurodegenerative conditions.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2020-09-17
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1111/jpi.12695
Anderer: cbg-7829
PMID: 32939783
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of pineal research
  Andere : J. Pineal Res.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 70 (1) Artikelnummer: e12695 Start- / Endseite: - Identifikator: -