The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein 
that controls insulin secretory granule biogenesis.

Carrat, Gaelle R; Haythorne, Elizabeth; Tomas, Alejandra; Haataja, Leena; Müller, Andreas; Arvan, Peter; Piunti, Alexandra; Cheng, Kaiying; Huang, Mutian; Pullen, Timothy J; Georgiadou, Eleni; Stylianides, Theodoros; Amirruddin, Nur Shabrina; Salem, Victoria; Distaso, Walter; Cakebread, Andrew; Heesom, Kate J; Lewis, Philip A; Hodson, David J; Briant, Linford J; Fung, Annie C H; Sessions, Richard B; Alpy, Fabien; Kong, Alice P S; Benke, Peter I; Torta, Federico; Teo, Adrian Kee Keong; Leclerc, Isabelle; Solimena, Michele; Wigley, Dale B; Rutter, Guy A

doi:10.1016/j.molmet.2020.101015

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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

Carrat, G. R., Haythorne, E., Tomas, A., Haataja, L., Müller, A., Arvan, P., et al. (2020). The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Molecular metabolism, 40: 101015. doi:10.1016/j.molmet.2020.101015.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-A36E-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-A36F-4

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Carrat, Gaelle R, Author
Haythorne, Elizabeth, Author
Tomas, Alejandra, Author
Haataja, Leena, Author
Müller, Andreas, Author
Arvan, Peter, Author
Piunti, Alexandra, Author
Cheng, Kaiying, Author
Huang, Mutian, Author
Pullen, Timothy J, Author
Georgiadou, Eleni, Author
Stylianides, Theodoros, Author
Amirruddin, Nur Shabrina, Author
Salem, Victoria, Author
Distaso, Walter, Author
Cakebread, Andrew, Author
Heesom, Kate J, Author
Lewis, Philip A, Author
Hodson, David J, Author
Briant, Linford J, Author
Fung, Annie C H, AuthorSessions, Richard B, AuthorAlpy, Fabien, AuthorKong, Alice P S, AuthorBenke, Peter I, AuthorTorta, Federico, AuthorTeo, Adrian Kee Keong, AuthorLeclerc, Isabelle, AuthorSolimena, Michele¹, Author Wigley, Dale B, AuthorRutter, Guy A, Author more..

Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692

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Abstract: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the identity of the transported lipids and thus the pathways through which STARD10 regulates β-cell function are not understood. The aim of this study was to identify the lipids transported and affected by STARD10 in the β-cell and the role of the protein in controlling proinsulin processing and insulin granule biogenesis and maturation.

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Dates: Date issued: 2020-10-01

Publication Status: Issued

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Identifiers: DOI: 10.1016/j.molmet.2020.101015
Other: cbg-7828
PMID: 32416313

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Title: Molecular metabolism

Other : Mol Metab

Source Genre: Journal

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Pages: - Volume / Issue: 40 Sequence Number: 101015 Start / End Page: - Identifier: -