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  Unlocking a signal of introgression from codons in Lachancea kluyveri using a mutation-selection model.

Landerer, C., O'Meara, B. C., Zaretzki, R., & Gilchrist, M. J. (2020). Unlocking a signal of introgression from codons in Lachancea kluyveri using a mutation-selection model. BMC evolutionary biology, 20(1): 109. doi:10.1186/s12862-020-01649-w.

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Landerer, Cedric1, Author           
O'Meara, Brian C, Author
Zaretzki, Russell, Author
Gilchrist, Michael J, Author
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: For decades, codon usage has been used as a measure of adaptation for translational efficiency and translation accuracy of a gene's coding sequence. These patterns of codon usage reflect both the selective and mutational environment in which the coding sequences evolved. Over this same period, gene transfer between lineages has become widely recognized as an important biological phenomenon. Nevertheless, most studies of codon usage implicitly assume that all genes within a genome evolved under the same selective and mutational environment, an assumption violated when introgression occurs. In order to better understand the effects of introgression on codon usage patterns and vice versa, we examine the patterns of codon usage in Lachancea kluyveri, a yeast which has experienced a large introgression. We quantify the effects of mutation bias and selection for translation efficiency on the codon usage pattern of the endogenous and introgressed exogenous genes using a Bayesian mixture model, ROC SEMPPR, which is built on mechanistic assumptions about protein synthesis and grounded in population genetics.

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 Dates: 2020-08-26
 Publication Status: Issued
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 Identifiers: DOI: 10.1186/s12862-020-01649-w
Other: cbg-7849
PMID: 32842959
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Title: BMC evolutionary biology
  Other : BMC Evol Biol
Source Genre: Journal
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Pages: - Volume / Issue: 20 (1) Sequence Number: 109 Start / End Page: - Identifier: -