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  Identifying the origin of local flexibility in a carbohydrate polymer

Anggara, K., Zhu, Y., Fittolani, G., Yu, Y., Tyrikos-Ergas, T., Delbianco, M., et al. (2021). Identifying the origin of local flexibility in a carbohydrate polymer. Proceedings of the National Academy of Sciences of the United States of America, 118(23): e2102168118. doi:10.1073/pnas.2102168118.

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 Creators:
Anggara, Kelvin, Author
Zhu, Yuntao1, Author              
Fittolani, Giulio2, Author              
Yu, Yang2, Author              
Tyrikos-Ergas, Theodore2, Author              
Delbianco, Martina2, Author              
Rauschenbach, Stephan, Author
Abb, Sabine, Author
Seeberger, Peter H.1, Author              
Kern, Klaus, Author
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              
2Martina Delbianco, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2559692              

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Free keywords: structure-property relationship; glycan flexibility; automated synthesis
 Abstract: The monomer sequence dictates the structure and properties of natural polymers. Such a structure property relationship is well known for polypeptides and polynucleotides but not for polysaccharides, the most abundant biopolymers on Earth. Here, we establish the structure property relationship for a polysaccharide at the atomic level by determining molecular flexibility of carbohydrate chains with defined sequences. The chain flexibility can be engineered one linkage at a time by chemical substitution and conformation change, highlighting how the primary and secondary structures of a carbohydrate dictate its flexibility a critical observable in the de novo design of carbohydrate materials. Our approach can be extended to establish the structure property relationship at the atomic level of any molecule that can be electrosprayed.Correlating the structures and properties of a polymer to its monomer sequence is key to understanding how its higher hierarchy structures are formed and how its macroscopic material properties emerge. Carbohydrate polymers, such as cellulose and chitin, are the most abundant materials found in nature whose structures and properties have been characterized only at the submicrometer level. Here, by imaging single-cellulose chains at the nanoscale, we determine the structure and local flexibility of cellulose as a function of its sequence (primary structure) and conformation (secondary structure). Changing the primary structure by chemical substitutions and geometrical variations in the secondary structure allow the chain flexibility to be engineered at the single-linkage level. Tuning local flexibility opens opportunities for the bottom-up design of carbohydrate materials.All data needed to evaluate the conclusion in the paper are present in the paper or SI Appendix.

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Language(s): eng - English
 Dates: 2021-06-012021
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1073/pnas.2102168118
BibTex Citekey: Anggarae2102168118
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 118 (23) Sequence Number: e2102168118 Start / End Page: - Identifier: ISSN: 0027-8424