Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies

Lazarevic, M., Djedovic, N., Stanisavljevic, S., Dimitrijevic, M., Stegnjaic, G., Krishnamoorthy, G., et al. (2021). Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. Journal of Neuroimmunology, 354: 577547. doi:10.1016/j.jneuroim.2021.577547.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Lazarevic, Milica1, Autor
Djedovic, Neda1, Autor
Stanisavljevic, Suzana1, Autor
Dimitrijevic, Mirjana1, Autor
Stegnjaic, Goran1, Autor
Krishnamoorthy, Gurumoorthy2, Autor           
Stojkovic, Marija Mostarica1, Autor
Miljkovic, Dorde1, Autor
Jevtic, Bojan1, Autor
Affiliations:
1external, ou_persistent22              
2Krishnamoorthy, Gurumoorthy / Neuroinflammation and Mucosal Immunology, Max Planck Institute of Biochemistry, Max Planck Society, ou_2173635              

Inhalt

einblenden:
ausblenden:
Schlagwörter: ALLERGIC ENCEPHALOMYELITIS; NERVOUS-SYSTEM; CELLS; MACROPHAGES; EXPRESSION; CD4; INDUCTION; MODEL; MYELIN; RECRUITMENTImmunology; Neurosciences & Neurology; EAE; CFA; CD4(+) T cells; CD8(+) macrophages;
 Zusammenfassung: Experimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple sclerosis model. Here, we compare clinical, cellular and molecular properties between syngeneic spinal cord homogenate (SCH)- and SCH + CFA-immunized Dark Agouti rats. EAE signs were observed earlier and the cumulative clinical score was higher without CFA. Also, a higher number of immune cells infiltrates in the spinal cords was noticed at the peak of EAE without CFA. High spinal cord abundance of CD8(+)CD11bc(+)MHC class II+ cells was detected in SCH-immunized rats. Myelin basic protein -specific response can be elicited in the cells from the lymph nodes draining the site of SCH immunization. This CFA-free EAE is a reliable multiple sclerosis model.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2021
 Publikationsstatus: Online veröffentlicht
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000640525500003
DOI: 10.1016/j.jneuroim.2021.577547
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Neuroimmunology
  Andere : J. Neuroimmunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : Elsevier
Seiten: - Band / Heft: 354 Artikelnummer: 577547 Start- / Endseite: - Identifikator: ISSN: 0165-5728
CoNE: https://pure.mpg.de/cone/journals/resource/954925481617