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  Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes

Immel, A., Key, F. M., Szolek, A., Barquera, R., Robinson, M. K., Harrison, G. F., et al. (2021). Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes. Molecular Biology and Evolution, 38(10): msab147, pp. 4059-4076. doi:10.1093/molbev/msab147.

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 Creators:
Immel, Alexander1, Author              
Key, Felix Michael1, Author              
Szolek, András, Author
Barquera, Rodrigo1, Author              
Robinson, Madeline K., Author
Harrison, Genelle F., Author
Palmer, William H., Author
Spyrou, Maria A.1, Author              
Susat, Julian, Author
Krause-Kyora, Ben1, Author              
Bos, Kirsten I.1, Author              
Forrest, Stephen, Author
Hernández-Zaragoza, Diana I.1, Author              
Sauter, Jürgen, Author
Solloch, Ute, Author
Schmidt, Alexander H., Author
Schuenemann, Verena J., Author
Reiter, Ella, Author
Kairies, Madita S., Author
Weiß, Rainer, Author
Arnold, Susanne, AuthorWahl, Joachim, AuthorHollenbach, Jill A., AuthorKohlbacher, Oliver, AuthorHerbig, Alexander1, Author              Norman, Paul J., AuthorKrause, Johannes1, 2, Author               more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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Free keywords: DNA, aDNA, HLA, plague, Yersinia pestis, human immunity, natural selection.
 Abstract: Pathogens and associated outbreaks of infectious disease exert selective pressure on human populations, and any changes in allele frequencies that result may be especially evident for genes involved in immunity. In this regard, the 1346-1353 Yersinia pestis-caused Black Death pandemic, with continued plague outbreaks spanning several hundred years, is one of the most devastating recorded in human history. To investigate the potential impact of Y. pestis on human immunity genes we extracted DNA from 36 plague victims buried in a mass grave in Ellwangen, Germany in the 16th century. We targeted 488 immune-related genes, including HLA, using a novel in-solution hybridization capture approach. In comparison with 50 modern native inhabitants of Ellwangen, we find differences in allele frequencies for variants of the innate immunity proteins Ficolin-2 and NLRP14 at sites involved in determining specificity. We also observed that HLA-DRB1*13 is more than twice as frequent in the modern population, whereas HLA-B alleles encoding an isoleucine at position 80 (I-80+), HLA C*06:02 and HLA-DPB1 alleles encoding histidine at position 9 are half as frequent in the modern population. Simulations show that natural selection has likely driven these allele frequency changes. Thus, our data suggests that allele frequencies of HLA genes involved in innate and adaptive immunity responsible for extracellular and intracellular responses to pathogenic bacteria, such as Y. pestis, could have been affected by the historical epidemics that occurred in Europe.

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Language(s): eng - English
 Dates: 2021-05-182021-10
 Publication Status: Published in print
 Pages: 18
 Publishing info: -
 Table of Contents: - Introduction
- Results
-- Archaeological and Anthropological Findings
-- The 16th Century Ellwangen Plague Victims Display Genetic Similarity with Modern Inhabitants
-- Two Immunity-Related Genes Harbor Strongly Differentiated single nucleotide polymorphisms
-- No Evidence for Role of CCR5-D32 in Protection from Y. pestis Infection
Discussion
-- Natural Selection Has Increased HLA-DRB*13 and Reduced HLA-B*51 and -C*06 Frequencies in Modern Individuals
-- Higher Incidence of KIR3DL1 Interaction with HLA-B in Plague Victims Than Modern Inhabitants of Ellwangen
- Discussion
- Materials and Methods
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/molbev/msab147
Other: shh2944
 Degree: -

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Title: Molecular Biology and Evolution
  Other : Mol. Biol. Evol.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 38 (10) Sequence Number: msab147 Start / End Page: 4059 - 4076 Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119