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  Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis

Ruiz-Ojeda, F. J., Wang, J., Baecker, T., Krueger, M., Zamani, S., Rosowski, S., et al. (2021). Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis. Molecular Metabolism, 45: 101147. doi:10.1016/j.molmet.2020.101147.

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Ruiz-Ojeda, Francisco Javier1, Autor
Wang, Jiefu1, Autor
Baecker, Theresa1, Autor
Krueger, Martin1, Autor
Zamani, Samira1, Autor
Rosowski, Simon1, Autor
Gruber, Tim1, Autor
Onogi, Yasuhiro1, Autor
Feuchtinger, Annette1, Autor
Schulz, Tim J.1, Autor
Faessler, Reinhard2, Autor           
Mueller, Timo D.1, Autor
Garcia-Caceres, Cristina1, Autor
Meier, Matthias1, Autor
Blueher, Matthias1, Autor
Ussar, Siegfried1, Autor
Affiliations:
1external, ou_persistent22              
2Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Schlagwörter: Endocrinology & Metabolism; Integrins; Kindlin-2; Insulin resistance; Adipose tissue; Obesity; Brown fat; Insulin receptor; Lipodystrophy;
 Zusammenfassung: Objective: Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. However, very little is known about the direct effects of impaired celle-matrix interaction in adipocyte function and insulin sensitivity. The objective of this study was to determine whether integrin activity can regulate insulin sensitivity in adipocytes and thereby systemic metabolism.
Methods: We characterized integrin activity in adipose tissue and its consequences on whole-body metabolism using adipose-selective deletion of beta 1 integrin (Itgb1(adipo-cre)) and Kindlin-2 (Kind2(adipo-cre)) in mice.
Results: We demonstrate that integrin signaling regulates white adipocyte insulin action and systemic metabolism. Consequently, loss of adipose integrin activity, similar to loss of adipose insulin receptors, results in a lipodystrophy-like phenotype and systemic insulin resistance. However, brown adipose tissue of Kind2(adipo-cre) and Itgb1(adipo-cre) mice is chronically hyperactivated and has increased substrate delivery, reduced endothelial basement membrane thickness, and increased endothelial vesicular transport.
Conclusions: Thus, we establish integrin-extracellular matrix interactions as key regulators of white and brown adipose tissue function and whole-body metabolism. (C) 2020 The Author(s). Published by Elsevier GmbH.

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Sprache(n): eng - English
 Datum: 2021
 Publikationsstatus: Online veröffentlicht
 Seiten: 16
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000631823500007
DOI: 10.1016/j.molmet.2020.101147
 Art des Abschluß: -

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Titel: Molecular Metabolism
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Amsterdam, Netherlands : Elsevier B.V.
Seiten: - Band / Heft: 45 Artikelnummer: 101147 Start- / Endseite: - Identifikator: ISSN: 2212-8778
CoNE: https://pure.mpg.de/cone/journals/resource/2212-8778