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  Cytomegalovirus distribution and evolution in hominines

Murthy, S., O’Brien, K., Agbor, A., Angedakin, S., Arandjelovic, M., Ayimisin, A. E., et al. (2019). Cytomegalovirus distribution and evolution in hominines. Virus Evolution, 5(2): vez015. doi:10.1093/ve/vez015.

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Murthy_Cytomegalovirus_VirEvo_2019.pdf (Publisher version), 682KB
 
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The Author(s) 2019. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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Murthy_Cytomegalovirus_VirEvo_2019-Suppl.pdf (Supplementary material), 8KB
 
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 Creators:
Murthy, Sripriya, Author
O’Brien, Kathryn, Author
Agbor, Anthony, Author
Angedakin, Samuel1, Author           
Arandjelovic, Milica2, Author           
Ayimisin, Ayuk Emmanuel1, Author           
Bailey, Emma1, Author           
Bergl, Richard A, Author
Brazzola, Gregory1, Author           
Dieguez, Paula1, Author           
Eno-Nku, Manasseh, Author
Eshuis, Henk1, Author           
Fruth, Barbara3, Author           
Gillespie, Thomas R, Author
Yuh, Yisa Ginath2, Author           
Gray, Maryke, Author
Herbinger, Ilka, Author
Jones, Sorrel1, Author           
Kehoe, Laura, Author
Kühl, Hjalmar S.2, Author           
Kujirakwinja, Deo, AuthorLee, Kevin1, Author           Madinda, Nadege Freda1, Author           Mitamba, Guillain, AuthorMuhindo, Emmanuel, AuthorNishuli, Radar, AuthorOrmsby, Lucy Jayne1, Author           Petrzelkova, Klara J, AuthorPlumptre, Andrew J, AuthorRobbins, Martha M.4, Author           Sommer, Volker, AuthorTer Heegde, Martijn, AuthorTodd, Angelique, AuthorTokunda, Raymond, AuthorWessling, Erin G.1, Author           Jarvis, Michael A, AuthorLeendertz, Fabian H, AuthorEhlers, Bernhard, AuthorCalvignac-Spencer, Sébastien, Author more..
Affiliations:
1Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497674              
2Great Ape Evolutionary Ecology and Conservation, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2149638              
3External Organizations, ou_persistent22              
4Gorillas, Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_2149637              

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 Abstract: Herpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs; genus Cytomegalovirus) infecting primates, which exhibit a strong signal of co-divergence with their hosts. Some herpesviruses are however known to have crossed species barriers. Based on a limited sampling of CMV diversity in the hominine (African great ape and human) lineage, we hypothesized that chimpanzees and gorillas might have mutually exchanged CMVs in the past. Here, we performed a comprehensive molecular screening of all 9 African great ape species/subspecies, using 675 fecal samples collected from wild animals. We identified CMVs in eight species/subspecies, notably generating the first CMV sequences from bonobos. We used this extended dataset to test competing hypotheses with various degrees of co-divergence/number of host switches while simultaneously estimating the dates of these events in a Bayesian framework. The model best supported by the data involved the transmission of a gorilla CMV to the panine (chimpanzee and bonobo) lineage and the transmission of a panine CMV to the gorilla lineage prior to the divergence of chimpanzees and bonobos, more than 800,000 years ago. Panine CMVs then co-diverged with their hosts. These results add to a growing body of evidence suggesting that viruses with a double-stranded DNA genome (including other herpesviruses, adenoviruses, and papillomaviruses) often jumped between hominine lineages over the last few million years.

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Language(s): eng - English
 Dates: 2019-09
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/ve/vez015
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Title: Virus Evolution
Source Genre: Journal
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Pages: - Volume / Issue: 5 (2) Sequence Number: vez015 Start / End Page: - Identifier: ISSN: 2057-1577