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  Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior

Koelsch, Y., Hahn, J., Sappington, A., Stemmer, M., Fernandes, A. M., Helmbrecht, T. O., et al. (2021). Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior. Neuron, 109(4), 645-662.e9. doi:10.1016/j.neuron.2020.12.003.

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Koelsch, Yvonne1, Autor           
Hahn, Joshua, Autor
Sappington, Anna, Autor
Stemmer, Manuel1, Autor           
Fernandes, António M.1, Autor           
Helmbrecht, Thomas O.1, Autor           
Lele, Shriya1, Autor           
Butrus, Salwan, Autor
Laurell, Eva1, Autor           
Arnold-Ammer, Irene1, Autor           
Shekhar, Karthik, Autor
Sanes, Joshua R., Autor
Baier, Herwig1, Autor           
Affiliations:
1Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society, ou_1128545              

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Schlagwörter: Neurosciences & Neurology;
 Zusammenfassung: Retinal ganglion cells (RGCs) form an array of feature detectors, which convey visual information to central brain regions. Characterizing RGC diversity is required to understand the logic of the underlying functional segregation. Using single-cell transcriptomics, we systematically classified RGCs in adult and larval zebra fish, thereby identifying marker genes for >30 mature types and several developmental intermediates. We used this dataset to engineer transgenic driver lines, enabling specific experimental access to a subset of RGC types. Expression of one or few transcription factors often predicts dendrite morphologies and axonal projections to specific tectal layers and extratectal targets. In vivo calcium imaging revealed that molecularly defined RGCs exhibit specific functional tuning. Finally, chemogenetic ablation of eomesa+ RGCs, which comprise melanopsin-expressing types with projections to a small subset of central targets, selectively impaired phototaxis. Together, our study establishes a framework for systematically studying the functional architecture of the visual system.

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Sprache(n): eng - English
 Datum: 2021-02-17
 Publikationsstatus: Erschienen
 Seiten: 28
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000632664600001
DOI: 10.1016/j.neuron.2020.12.003
 Art des Abschluß: -

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Titel: Neuron
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Cambridge, Mass. : Cell Press
Seiten: - Band / Heft: 109 (4) Artikelnummer: - Start- / Endseite: 645 - 662.e9 Identifikator: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565