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  Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies

Slaninová, J., Hackenberg, M., & Fahrenholz, F. (1991). Comparison of binding affinities of a series of oxytocin analogues to uterine and mammary gland receptors and their biological potencies. Collection of Czechoslovak Chemical Communications, 56(4), 939-943. doi:10.1135/cccc19910939.

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Genre: Journal Article

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 Creators:
Slaninová, Jiřina1, Author
Hackenberg, Mario2, Author           
Fahrenholz, Falk2, Author           
Affiliations:
1Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, 166 10 Prague 6, Czechoslovakia, ou_persistent22              
2Emeritusgroup Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_3273414              

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 Abstract: The affinity of 12 oxytocin analogues of similar structure but differences in conformational freedom and agonistic and antagonistic properties to receptors in guinea pig uterus and rat mammary gland membrane preparations was determined by competitive binding experiments using tritiated oxytocin. The values obtained for the apparent dissociation constant KD were compared to the values of biological activities from classical pharmacological tests (uterotonic test in vitro and galactogogic test in vivo).

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Language(s): eng - English
 Dates: 1991-04-01
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1135/cccc19910939
 Degree: -

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Title: Collection of Czechoslovak Chemical Communications
  Other : Collect. Czech. Chem. Commun.
Source Genre: Journal
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Affiliations:
Publ. Info: Prague : Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic [etc.]
Pages: - Volume / Issue: 56 (4) Sequence Number: - Start / End Page: 939 - 943 Identifier: ISSN: 0010-0765
CoNE: https://pure.mpg.de/cone/journals/resource/954925391300