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  Photoreactive Agonists and Antagonists of Neuroypophysial Hormones for Receptor Studies

Fahrenholz, F., Kojro, E., & Boer, R. (1987). Photoreactive Agonists and Antagonists of Neuroypophysial Hormones for Receptor Studies. In D. Theodoropoulos (Ed.), European Peptide Symposium: Peptides (pp. 469-472). Berlin: De Gruyter. doi:10.1515/9783110864243-109.

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Genre: Conference Paper

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 Creators:
Fahrenholz, Falk1, Author           
Kojro, Elzbieta1, Author           
Boer, Rainer1, Author           
Affiliations:
1Department of Physical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_3264819              

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 Abstract: Photoreactive analogues of vasopressin have been synthesized and used to identify vasopressin receptor proteins in plasma membranes from different target organs (1,2):V1 vasopressin receptors (coupled to Ca2+ -mobilization) in rat liver and V2 vasopressin receptors (coupled to adenylate cyclase) in kidney medulla from different mammalian species. The question as to whether vasopressin agonists and antagonists interact with the same subunits of vasopressin receptor proteins remains open. Furthermore, at present we have no information which amino acid residues in the vasopressin molecule are close to the hormone binding site in the hormone-receptor complex. In this report we describe the synthesis of potent photoreactive vasopressin agonists and antagonists an their employment in receptor studies to answer these questions.

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Language(s): eng - English
 Dates: 19862019-10-081987-05-01
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1515/9783110864243-109
 Degree: -

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Title: Proceedings of the 19th European Peptide Symposium
Place of Event: Porto Carras, Chalkidiki, Greece
Start-/End Date: 1986-08-31 - 1986-09-05

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Title: European Peptide Symposium: Peptides
Source Genre: Proceedings
 Creator(s):
Theodoropoulos, Dimitrios1, Editor
Affiliations:
1 Laboratory of Organic Chemistry, University of Patras, Greece, ou_persistent22            
Publ. Info: Berlin : De Gruyter
Pages: 684 Volume / Issue: - Sequence Number: - Start / End Page: 469 - 472 Identifier: DOI: 10.1515/9783110864243
ISBN: 978-3110864243