Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Validating layer-specific VASO across species

Huber, L., Poser, B. A., Kaas, A. L., Fear, E. J., Dresbach, S., Berwick, J., et al. (2021). Validating layer-specific VASO across species. NeuroImage, 237: 118195. doi:10.1016/j.neuroimage.2021.118195.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Huber_2021.pdf (Verlagsversion), 3MB
Name:
Huber_2021.pdf
Beschreibung:
-
OA-Status:
Gold
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Huber, Laurentius1, Autor
Poser, Benedikt A.1, Autor
Kaas, Amanda L.1, Autor
Fear, Elizabeth J.2, Autor
Dresbach, Sebastian1, Autor
Berwick, Jason3, Autor
Goebel, Rainer1, Autor
Turner, Robert4, 5, Autor           
Kennerley, Aneurin J.2, Autor
Affiliations:
1Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
2Hull-York-Medical-School, University of York, United Kingdom, ou_persistent22              
3Department of Psychology, University of Sheffield, United Kingdom, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
5Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Cerebral blood volume; Concurrent imaging; Depth-dependent fMRI; Draining vein; Laminar; Layer; MION; Optical imaging spectroscopy; Pre-clinical; Somatosensory stimulation; Sub-millimetre; VASO.; fMRI
 Zusammenfassung: Cerebral blood volume (CBV) has been shown to be a robust and important physiological parameter for quantitative interpretation of functional (f)MRI, capable of delivering highly localized mapping of neural activity. Indeed, with recent advances in ultra-high-field (≥7T) MRI hardware and associated sequence libraries, it has become possible to capture non-invasive CBV weighted fMRI signals across cortical layers. One of the most widely used approaches to achieve this (in humans) is through vascular-space-occupancy (VASO) fMRI. Unfortunately, the exact contrast mechanisms of layer-dependent VASO fMRI have not been validated for human fMRI and thus interpretation of such data is confounded. Here we validate the signal source of layer-dependent SS-SI VASO fMRI using multi-modal imaging in a rat model in response to neuronal activation (somatosensory cortex) and respiratory challenge (hypercapnia). In particular VASO derived CBV measures are directly compared to concurrent measures of total haemoglobin changes from high resolution intrinsic optical imaging spectroscopy (OIS). Quantified cortical layer profiling is demonstrated to be in agreement between VASO and contrast enhanced fMRI (using monocrystalline iron oxide nanoparticles, MION). Responses show high spatial localisation to layers of cortical processing independent of confounding large draining veins which can hamper BOLD fMRI studies, (depending on slice positioning). Thus, a cross species comparison is enabled using VASO as a common measure. We find increased VASO based CBV reactivity (3.1 ± 1.2 fold increase) in humans compared to rats. Together, our findings confirm that the VASO contrast is indeed a reliable estimate of layer-specific CBV changes. This validation study increases the neuronal interpretability of human layer-dependent VASO fMRI as an appropriate method in neuroscience application studies, in which the presence of large draining intracortical and pial veins limits neuroscientific inference with BOLD fMRI.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2021-05-172020-07-242021-05-192021-05-242021-08-15
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.neuroimage.2021.118195
Anderer: epub 2021
PMID: 34038769
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : 16.Vidi.178.052
Förderprogramm : -
Förderorganisation : Dutch Research Council (NWO)
Projektname : -
Grant ID : R01MH/111444
Förderprogramm : -
Förderorganisation : National Institute for Health (NIH)
Projektname : -
Grant ID : 945539
Förderprogramm : Horizon 2020
Förderorganisation : European Union
Projektname : -
Grant ID : MR/M013553/1
Förderprogramm : -
Förderorganisation : Medical Research Council (MRC)
Projektname : -
Grant ID : 093069/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust (WT)

Quelle 1

einblenden:
ausblenden:
Titel: NeuroImage
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 237 Artikelnummer: 118195 Start- / Endseite: - Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166