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  Validating layer-specific VASO across species

Huber, L., Poser, B. A., Kaas, A. L., Fear, E. J., Dresbach, S., Berwick, J., et al. (2021). Validating layer-specific VASO across species. NeuroImage, 237: 118195. doi:10.1016/j.neuroimage.2021.118195.

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 Creators:
Huber, Laurentius1, Author
Poser, Benedikt A.1, Author
Kaas, Amanda L.1, Author
Fear, Elizabeth J.2, Author
Dresbach, Sebastian1, Author
Berwick, Jason3, Author
Goebel, Rainer1, Author
Turner, Robert4, 5, Author              
Kennerley, Aneurin J.2, Author
Affiliations:
1Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
2Hull-York-Medical-School, University of York, United Kingdom, ou_persistent22              
3Department of Psychology, University of Sheffield, United Kingdom, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
5Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, United Kingdom, ou_persistent22              

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Free keywords: Cerebral blood volume; Concurrent imaging; Depth-dependent fMRI; Draining vein; Laminar; Layer; MION; Optical imaging spectroscopy; Pre-clinical; Somatosensory stimulation; Sub-millimetre; VASO.; fMRI
 Abstract: Cerebral blood volume (CBV) has been shown to be a robust and important physiological parameter for quantitative interpretation of functional (f)MRI, capable of delivering highly localized mapping of neural activity. Indeed, with recent advances in ultra-high-field (≥7T) MRI hardware and associated sequence libraries, it has become possible to capture non-invasive CBV weighted fMRI signals across cortical layers. One of the most widely used approaches to achieve this (in humans) is through vascular-space-occupancy (VASO) fMRI. Unfortunately, the exact contrast mechanisms of layer-dependent VASO fMRI have not been validated for human fMRI and thus interpretation of such data is confounded. Here we validate the signal source of layer-dependent SS-SI VASO fMRI using multi-modal imaging in a rat model in response to neuronal activation (somatosensory cortex) and respiratory challenge (hypercapnia). In particular VASO derived CBV measures are directly compared to concurrent measures of total haemoglobin changes from high resolution intrinsic optical imaging spectroscopy (OIS). Quantified cortical layer profiling is demonstrated to be in agreement between VASO and contrast enhanced fMRI (using monocrystalline iron oxide nanoparticles, MION). Responses show high spatial localisation to layers of cortical processing independent of confounding large draining veins which can hamper BOLD fMRI studies, (depending on slice positioning). Thus, a cross species comparison is enabled using VASO as a common measure. We find increased VASO based CBV reactivity (3.1 ± 1.2 fold increase) in humans compared to rats. Together, our findings confirm that the VASO contrast is indeed a reliable estimate of layer-specific CBV changes. This validation study increases the neuronal interpretability of human layer-dependent VASO fMRI as an appropriate method in neuroscience application studies, in which the presence of large draining intracortical and pial veins limits neuroscientific inference with BOLD fMRI.

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Language(s): eng - English
 Dates: 2021-05-172020-07-242021-05-192021-05-242021-08-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2021.118195
Other: epub 2021
PMID: 34038769
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Project name : -
Grant ID : 16.Vidi.178.052
Funding program : -
Funding organization : Dutch Research Council (NWO)
Project name : -
Grant ID : R01MH/111444
Funding program : -
Funding organization : National Institute for Health
Project name : -
Grant ID : 945539
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : MR/M013553/1
Funding program : -
Funding organization : Medical Research Council (MRC)
Project name : -
Grant ID : 093069/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust (WT)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 237 Sequence Number: 118195 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166