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  Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes

Immel, A., Key, F. M., Szolek, A., Barquera, R., Robinson, M. K., Harrison, G. F., et al. (2021). Analysis of genomic DNA from medieval plague victims suggests long-term effect of Yersinia pestis on human immunity genes. Molecular Biology and Evolution, 38(10), 4059-4076. doi:10.1093/molbev/msab147.

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This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.

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Immel, Alexander1, Author           
Key, Felix Michael1, Author                 
Szolek, András, Author
Barquera, Rodrigo1, Author                 
Robinson, Madeline K., Author
Harrison, Genelle F., Author
Palmer, William H., Author
Spyrou, Maria A.1, Author                 
Susat, Julian, Author
Krause-Kyora, Ben1, Author           
Bos, Kirsten I.1, Author                 
Forrest, Stephen, Author
Hernández-Zaragoza, Diana I.1, Author           
Sauter, Jürgen, Author
Solloch, Ute, Author
Schmidt, Alexander H., Author
Schuenemann, Verena J., Author
Reiter, Ella, Author
Kairies, Madita S., Author
Weiß, Rainer, Author
Arnold, Susanne, AuthorWahl, Joachim, AuthorHollenbach, Jill A., AuthorKohlbacher, Oliver, AuthorHerbig, Alexander1, Author                 Norman, Paul J., AuthorKrause, Johannes1, 2, 3, Author                  more..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              
3Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_3222712              

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 Abstract: Pathogens and associated outbreaks of infectious disease exert selective pressure on human populations, and any changes in allele frequencies that result may be especially evident for genes involved in immunity. In this regard, the 1346-1353 Yersinia pestis-caused Black Death pandemic, with continued plague outbreaks spanning several hundred years, is one of the most devastating recorded in human history. To investigate the potential impact of Y. pestis on human immunity genes we extracted DNA from 36 plague victims buried in a mass grave in Ellwangen, Germany in the 16th century. We targeted 488 immune-related genes, including HLA, using a novel in-solution hybridization capture approach. In comparison with 50 modern native inhabitants of Ellwangen, we find differences in allele frequencies for variants of the innate immunity proteins Ficolin-2 and NLRP14 at sites involved in determining specificity. We also observed that HLA-DRB1*13 is more than twice as frequent in the modern population, whereas HLA-B alleles encoding an isoleucine at position 80 (I-80+), HLA C*06:02 and HLA-DPB1 alleles encoding histidine at position 9 are half as frequent in the modern population. Simulations show that natural selection has likely driven these allele frequency changes. Thus, our data suggests that allele frequencies of HLA genes involved in innate and adaptive immunity responsible for extracellular and intracellular responses to pathogenic bacteria, such as Y. pestis, could have been affected by the historical epidemics that occurred in Europe.

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Language(s): eng - English
 Dates: 2021-05-182021-10
 Publication Status: Issued
 Pages: 45
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1093/molbev/msab147
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Title: Molecular Biology and Evolution
Source Genre: Journal
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Pages: - Volume / Issue: 38 (10) Sequence Number: - Start / End Page: 4059 - 4076 Identifier: ISSN: 0737-4038
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119