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  Whole-brain dynamics in aging: Disruptions in functional connectivity and the role of the rich club

Escrichs, A., Biarnes, C., Garre-Olmo, J., Fernández-Real, J. M., Ramos, R., Pamplona, R., et al. (2021). Whole-brain dynamics in aging: Disruptions in functional connectivity and the role of the rich club. Cerebral Cortex, 31(5), 2466-2481. doi:10.1093/cercor/bhaa367.

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Genre: Journal Article

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 Creators:
Escrichs, Anira, Author
Biarnes, Carles, Author
Garre-Olmo, Josep, Author
Fernández-Real, José Manuel, Author
Ramos, Rafel, Author
Pamplona, Reinald, Author
Brugada, Ramon, Author
Serena, Joaquin, Author
Ramió-Torrentà, Lluís, Author
Coll-De-Tuero, Gabriel, Author
Gallart, Luís, Author
Barretina, Jordi, Author
Vilanova, Joan C, Author
Mayneris-Perxachs, Jordi, Author
Essig, Marco, Author
Figley, Chase R, Author
Pedraza, Salvador, Author
Puig, Josep, Author
Deco, Gustavo1, Author              
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

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Free keywords: Aging; Metastability; Resting-state fMRI; Rich-club; Whole-brain dynamics
 Abstract: Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here, we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50-64 years versus older group (n = 310); age range, 65-91 years). Applying the intrinsic-ignition framework to assess the effect of spontaneous local activation events on local-global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.

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Language(s): eng - English
 Dates: 2020-10-292020-07-152020-10-292020-12-202021-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhaa367
PMID: 33350451
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 31 (5) Sequence Number: - Start / End Page: 2466 - 2481 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440