Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
 Lokale TagsFreigabegeschichteDetailsÜbersicht
  Whole-brain dynamics in aging: Disruptions in functional connectivity and the role of the rich club

Escrichs, A., Biarnes, C., Garre-Olmo, J., Fernández-Real, J. M., Ramos, R., Pamplona, R., et al. (2021). Whole-brain dynamics in aging: Disruptions in functional connectivity and the role of the rich club. Cerebral Cortex, 31(5), 2466-2481. doi:10.1093/cercor/bhaa367.

Item is

 

einblenden: alle ausblenden: alle

Basisdaten

einblenden: ausblenden:
Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0008-B7AB-9 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000F-748E-F
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Escrichs_pre.pdf (Preprint), 2MB
Öffnen   Speichern
Datei-Permalink:
https://hdl.handle.net/21.11116/0000-000D-BB18-6
Name:
Escrichs_pre.pdf
Beschreibung:
-
OA-Status:
Grün
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Öffnen
Copyright Datum:
-
Copyright Info:
-
Lizenz:
https://creativecommons.org/licenses/by-nc-nd/4.0/

Externe Referenzen

einblenden:
ausblenden:
externe Referenz:
https://academic.oup.com/cercor/article/31/5/2466/6043816 (Verlagsversion)
Beschreibung:
-
OA-Status:
Sonstiges

Urheber

einblenden:
ausblenden:
 Urheber:
Escrichs, Anira, Autor
Biarnes, Carles, Autor
Garre-Olmo, Josep, Autor
Fernández-Real, José Manuel, Autor
Ramos, Rafel, Autor
Pamplona, Reinald, Autor
Brugada, Ramon, Autor
Serena, Joaquin, Autor
Ramió-Torrentà, Lluís, Autor
Coll-De-Tuero, Gabriel, Autor
Gallart, Luís, Autor
Barretina, Jordi, Autor
Vilanova, Joan C, Autor
Mayneris-Perxachs, Jordi, Autor
Essig, Marco, Autor
Figley, Chase R, Autor
Pedraza, Salvador, Autor
Puig, Josep, Autor
Deco, Gustavo1, Autor           
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Aging; Metastability; Resting-state fMRI; Rich-club; Whole-brain dynamics
 Zusammenfassung: Normal aging causes disruptions in the brain that can lead to cognitive decline. Resting-state functional magnetic resonance imaging studies have found significant age-related alterations in functional connectivity across various networks. Nevertheless, most of the studies have focused mainly on static functional connectivity. Studying the dynamics of resting-state brain activity across the whole-brain functional network can provide a better characterization of age-related changes. Here, we employed two data-driven whole-brain approaches based on the phase synchronization of blood-oxygen-level-dependent signals to analyze resting-state fMRI data from 620 subjects divided into two groups (middle-age group (n = 310); age range, 50-64 years versus older group (n = 310); age range, 65-91 years). Applying the intrinsic-ignition framework to assess the effect of spontaneous local activation events on local-global integration, we found that the older group showed higher intrinsic ignition across the whole-brain functional network, but lower metastability. Using Leading Eigenvector Dynamics Analysis, we found that the older group showed reduced ability to access a metastable substate that closely overlaps with the so-called rich club. These findings suggest that functional whole-brain dynamics are altered in aging, probably due to a deficiency in a metastable substate that is key for efficient global communication in the brain.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2020-10-292020-07-152020-10-292020-12-202021-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/cercor/bhaa367
PMID: 33350451
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : -
Grant ID : SLT002/16/00250
Förderprogramm : -
Förderorganisation : Government of Catalonia's Department of Health's Pla Estrategic de Recerca i Innovacio en Salut (PERIS)
Projektname : -
Grant ID : RTI2018-099200-B-I00
Förderprogramm : -
Förderorganisation : Spanish Ministry of Science, Innovation
Projektname : -
Grant ID : 2017SGR696
Förderprogramm : -
Förderorganisation : Generalitat of Catalonia
Projektname : -
Grant ID : PSI201675688-P
Förderprogramm : -
Förderorganisation : Spanish Ministry of Economy and Competitiveness, Spain
Projektname : -
Grant ID : 785907
Förderprogramm : -
Förderorganisation : European Union (EU)
Projektname : -
Grant ID : 2017 SGR 1545
Förderprogramm : -
Förderorganisation : Catalan Research Support, Spain
Projektname : -
Grant ID : 201725.33
Förderprogramm : -
Förderorganisation : La Marato TV3

Quelle 1

einblenden:
ausblenden:
Titel: Cerebral Cortex
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Oxford University Press
Seiten: - Band / Heft: 31 (5) Artikelnummer: - Start- / Endseite: 2466 - 2481 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440