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  Genetic variation in the oxytocin system and its link to social motivation in human infants

Krol, K. M., Namaky, N., Monakhov, M. V., Lai, P. S., Ebstein, R., & Grossmann, T. (2021). Genetic variation in the oxytocin system and its link to social motivation in human infants. Psychoneuroendocrinology, 131: 105290. doi:10.1016/j.psyneuen.2021.105290.

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 Creators:
Krol, K. M.1, 2, Author              
Namaky, Nauder1, Author
Monakhov, Mikhail V.3, 4, Author
Lai, Poh San5, Author
Ebstein, Richard4, 6, Author
Grossmann, Tobias1, 2, Author              
Affiliations:
1Department of Psychology, University of Virginia, Charlottesville, VA, USA, ou_persistent22              
2Max Planck Research Group Early Social Development, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356545              
3Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA, ou_persistent22              
4Department of Psychology, National University of Singapore, ou_persistent22              
5Department of Paediatrics, National University of Singapore, ou_persistent22              
6China Center for Behavioral Economics and Finance, Southwestern University of Finance and Economics, Chengdu, China, ou_persistent22              

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Free keywords: Frontal asymmetry; Oxytocin; FNIRS; Eyetracking; Infant; Emotion
 Abstract: Frontal brain asymmetry has been linked to motivational processes in infants and adults, with left lateralization reflecting motivation to approach and right lateralization reflecting motivation to withdraw. We examined the hypothesis that variability in infants’ social motivation may be linked to genetic variation in the oxytocin system. Eleven-month-old infants’ brain responses and looking preferences to smiling and frowning individuals were assessed in conjunction with a polymorphism in CD38 (rs3796863) linked to autism spectrum disorder (ASD) and reduced oxytocin. Frontal brain asymmetry and looking preferences differed as a function of CD38 genotype. While non-risk A-allele carriers displayed left lateralization to smiling faces (approach) and a heightened looking preference for the individual who smiled, infants with the CC (ASD risk) genotype displayed withdrawal from smiling faces and a preference for the individual who frowned. Findings demonstrate that the oxytocin system is linked to brain and behavioral markers of social motivation in infancy.

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Language(s): eng - English
 Dates: 2021-05-242021-02-152021-05-252021-05-292021-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.psyneuen.2021.105290
Other: epub 2021
PMID: 34091402
 Degree: -

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Title: Psychoneuroendocrinology
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 131 Sequence Number: 105290 Start / End Page: - Identifier: ISSN: 0306-4530
CoNE: https://pure.mpg.de/cone/journals/resource/954925514499