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  Health monitoring in birds using bio‑loggers and whole blood transcriptomics

Jax, E., Mueller, I., Börno, S., Borlinghaus, H., Eriksson, G., Fricke, E., et al. (2021). Health monitoring in birds using bio‑loggers and whole blood transcriptomics. Scientific Reports, 11: 10815. doi:10.1038/s41598-021-90212-8.

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 Creators:
Jax, Elinor1, 2, Author           
Mueller, Inge1, Author           
Börno, Stefan3, Author           
Borlinghaus, Hanna, Author
Eriksson, Gustaw, Author
Fricke, Evi, Author
Timmermann, Bernd3, Author           
Pendl, Helene, Author
Fiedler, Wolfgang1, Author           
Klein, Karsten, Author
Schreiber, Falk, Author
Wikelski, Martin1, Author           
Magor, Katharine E., Author
Kraus, Robert H. S.1, Author           
Affiliations:
1Department of Migration, Max Planck Institute of Animal Behavior, Max Planck Society, ou_3054975              
2IMPRS for Organismal Biology, Radolfzell, Seewiesen, Max Planck Institut für Ornithologie, Max Planck Society, ou_3172953              
3Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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 Abstract: Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases.

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Language(s): eng - English
 Dates: 2021-05-062021-05-24
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41598-021-90212-8
Other: Immediate Open Access
 Degree: -

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 11 Sequence Number: 10815 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322