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  Microstructural plasticity in nociceptive pathways after spinal cord injury

Kyathanahally, S. P., Azzarito, M., Rosner, J., Calhoun, V. D., Blaiotta, C., Ashburner, J., et al. (2021). Microstructural plasticity in nociceptive pathways after spinal cord injury. Journal of Neurology, Neurosurgery & Psychiatry. doi:10.1136/jnnp-2020-325580.

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 Creators:
Kyathanahally, Sreenath P.1, Author
Azzarito, Michela1, Author
Rosner, Jan1, 2, Author
Calhoun, Vince D.3, Author
Blaiotta, Claudia4, Author
Ashburner, John4, Author
Weiskopf, Nikolaus5, Author           
Wiech, Katja6, Author
Friston, Karl4, Author
Ziegler, Gabriel7, Author
Freund, Patrick1, 4, 5, Author           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
2Department of Neurology, University of Bern, Switzerland, ou_persistent22              
3Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia Institute of Technology, Emory University, Atlanta, GA, USA, ou_persistent22              
4Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
6Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
7German Center for Neurodegenerative Diseases, Magdeburg, Germany, ou_persistent22              

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 Abstract: Objective: To track the interplay between (micro-) structural changes along the trajectories of nociceptive pathways and its relation to the presence and intensity of neuropathic pain (NP) after spinal cord injury (SCI). Methods: A quantitative neuroimaging approach employing a multiparametric mapping protocol was used, providing indirect measures of myelination (via contrasts such as magnetisation transfer (MT) saturation, longitudinal relaxation (R1)) and iron content (via effective transverse relaxation rate (R2*)) was used to track microstructural changes within nociceptive pathways. In order to characterise concurrent changes along the entire neuroaxis, a combined brain and spinal cord template embedded in the statistical parametric mapping framework was used. Multivariate source-based morphometry was performed to identify naturally grouped patterns of structural variation between individuals with and without NP after SCI. Results: In individuals with NP, lower R1 and MT values are evident in the primary motor cortex and dorsolateral prefrontal cortex, while increases in R2* are evident in the cervical cord, periaqueductal grey (PAG), thalamus and anterior cingulate cortex when compared with pain-free individuals. Lower R1 values in the PAG and greater R2* values in the cervical cord are associated with NP intensity. Conclusions: The degree of microstructural changes across ascending and descending nociceptive pathways is critically implicated in the maintenance of NP. Tracking maladaptive plasticity unravels the intimate relationships between neurodegenerative and compensatory processes in NP states and may facilitate patient monitoring during therapeutic trials related to pain and neuroregeneration.

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Language(s): eng - English
 Dates: 2021-05-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1136/jnnp-2020-325580
Other: online ahead of print
PMID: 34039630
 Degree: -

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Project name : -
Grant ID : 616905
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 602186
Funding program : (681094)
Funding organization : European Commission
Project name : Horizon 2020
Grant ID : -
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : R01EB020407 and R01MH118695
Funding program : -
Funding organization : National Institute of Health

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Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
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Publ. Info: London : British Medical Association
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000