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Abstract:
Using human red cell ghosts, it was shown that external phlorizin inhibits Cl− and I− equilibrium exchange. Internal phlorizin has little effect on I− exchange and no detectable effect on Cl− exchange. This asymmetry is similar to that observed with the much more slowly exchanging SO42− and different from that of sugars like l-arabinose or d-xylose which are inhibited by phlorizin from either surface.