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  Neutrophils self-limit swarming to contain bacterial growth in vivo

Kienle, K., Glaser, K. M., Eickhoff, S., Mihlan, M., Knöpper, K., Reátegui, E., et al. (2021). Neutrophils self-limit swarming to contain bacterial growth in vivo. Science, 372: eabe7729. doi:10.1126/science.abe7729.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-C5D3-B Version Permalink: https://hdl.handle.net/21.11116/0000-0009-3DA3-B
Genre: Journal Article

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This is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in Science 372 June 18, eabe7729, DOI: 10.1126/science.abe7729
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https://science.sciencemag.org/content/372/6548/eabe7729 (Publisher version)
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 Creators:
Kienle, Korbinian1, Author
Glaser, Katharina M1, Author
Eickhoff, Sarah2, Author
Mihlan, Michael1, Author
Knöpper, Konrad2, Author
Reátegui, Eduardo2, Author
Epple, Maximilian W1, Author
Gunzer, Matthias2, Author
Baumeister, Ralf2, Author
Tarrant, Teresa K2, Author
Germain, Ronald N2, Author
Irimia, Daniel2, Author
Kastenmüller, Wolfgang2, Author
Lämmermann, Tim1, Author           
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1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_1565141              
2External Organizations, ou_persistent22              

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 Abstract: Neutrophils communicate with each other to form swarms in infected organs. Coordination of this population response is critical for the elimination of bacteria and fungi. Using transgenic mice, we found that neutrophils have evolved an intrinsic mechanism to self-limit swarming and avoid uncontrolled aggregation during inflammation. G protein–coupled receptor (GPCR) desensitization acts as a negative feedback control to stop migration of neutrophils when they sense high concentrations of self-secreted attractants that initially amplify swarming. Interference with this process allows neutrophils to scan larger tissue areas for microbes. Unexpectedly, this does not benefit bacterial clearance as containment of proliferating bacteria by neutrophil clusters becomes impeded. Our data reveal how autosignaling stops self-organized swarming behavior and how the finely tuned balance of neutrophil chemotaxis and arrest counteracts bacterial escape.

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Language(s): eng - English
 Dates: 2021-06-18
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.abe7729
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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 372 Sequence Number: eabe7729 Start / End Page: - Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1