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  Defining the qualities of high-quality palladium on carbon catalysts for hydrogenolysis

Crawford, C., Qiao, Y., Liu, Y., Huang, D., Yan, W., Seeberger, P. H., et al. (2021). Defining the qualities of high-quality palladium on carbon catalysts for hydrogenolysis. Organic Process Research & Development, 25(7), 1573-1578. doi:10.1021/acs.oprd.0c00536.

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Crawford, Conor1, Author                 
Qiao, Yan, Author
Liu, Yequn, Author
Huang, Dongmei, Author
Yan, Wenjun, Author
Seeberger, Peter H.1, Author           
Oscarson, Stefan, Author
Chen, Shuai, Author
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: heterogeneous catalysis, global deptrotectioin, glycans, total synthesis
 Abstract: Palladium-catalyzed hydrogenolysis is often the final step in challenging natural product total syntheses and a key step in industrial processes producing fine chemicals. Here, we demonstrate that there is wide variability in the efficiency of commercial sources of palladium on carbon (Pd/C) resulting in significant differences in selectivity, reaction times, and yields. We identified the physicochemical properties of efficient catalysts for hydrogenolysis: (1) small Pd/PdO particle size (2) homogeneous distribution of Pd/PdO on the carbon support, and (3) palladium oxidation state are good predictors of catalytic efficiency. Now chemists can identify and predict a catalyst’s efficiency prior to the use of valuable synthetic material and time.

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Language(s): eng - English
 Dates: 2021-06-232021
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1021/acs.oprd.0c00536
BibTex Citekey: doi:10.1021/acs.oprd.0c00536
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Title: Organic Process Research & Development
  Other : Org. Process Res. Dev.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 25 (7) Sequence Number: - Start / End Page: 1573 - 1578 Identifier: ISSN: 1083-6160