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  Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases

Lobato Gómez, M., Huang, X., Alvarez, D., He, W., Baysal, C., Zhu, C., et al. (2021). Contributions of the international plant science community to the fight against human infectious diseases – part 1: epidemic and pandemic diseases. Plant Biotechnology Journal, 19(10), 1901-1920. doi:10.1111/pbi.13657.

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Genre: Journal Article
Alternative Title : Plant Biotechnology Journal

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 Creators:
Lobato Gómez, Maria1, Author
Huang, Xin1, Author
Alvarez, Derry1, Author
He, Wenshu1, Author
Baysal, Can1, Author
Zhu, Changfu1, Author
Armario-Najera, Victoria1, Author
Blanco Perera, Amaya1, Author
Cerda Bennasser, Pedro1, Author
Saba-Mayoral, Andera1, Author
Sobrino-Mengual, Guillermo1, Author
Vargheese, Ashwin1, Author
Abranches, Rita1, Author
Abreu, Isabel Alexandra1, Author
Balamurugan, Shanmugaraj1, Author
Bock, R.2, Author              
Buyel, Johannes.F.1, Author
da Cunha1, Author
B, Nicolau1, Author
Daniell, Henry1, Author
Faller, Roland1, AuthorFolgado, André1, AuthorGowtham, Iyappan1, AuthorHäkkinen, SuviT.1, AuthorShashi, Kumar1, AuthorKumar Ramalingam, Sathish1, AuthorLacorte, Cristiano1, AuthorLomonossoff, George P.1, AuthorLuís, Ines M.1, AuthorMa, Julian K.-C.1, AuthorMcDonald, Karen. A.1, AuthorMurad, Andre1, AuthorNandi, Somen1, AuthorO’Keef, Barry1, AuthorOksman-Caldentey, Kirsi-Marja1, AuthorParthiban, Subramanian1, AuthorPaul, MathewJ.1, AuthorPonndorf, Daniel1, AuthorRech, Elibio1, AuthorRodrigues, Julio C.M.1, AuthorRuf, Stephanie1, AuthorSchillberg, Stefan1, AuthorSchwestka, Jennifer1, AuthorShah, Priya S.1, AuthorSingh, Rahul1, AuthorStoger, Eva1, AuthorTwyman, Richard M.1, AuthorVarghese, Inchakalody P.1, AuthorVianna, Giovanni R.1, AuthorWebster, Gina1, AuthorWilbers, Ruud H.P.1, AuthorCapell, Teresa1, AuthorChristou, Paul1, Author more..
Affiliations:
1external, ou_persistent22              
2Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753326              

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Free keywords: Molecular farming, plant-made pharmaceuticals, HIV/AIDS, SARS-CoV-2, COVID-19
 Abstract: Summary Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause ~17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programs, hygiene measures, and drugs that suppress the pathogen, treat the disease symptoms, or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focusing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.

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Language(s): eng - English
 Dates: 2021-06-28
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/pbi.13657
 Degree: -

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Title: Plant Biotechnology Journal
  Other : Plant Biotechnol. J.
Source Genre: Journal
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Affiliations:
Publ. Info: Oxford : Blackwell Pub.
Pages: - Volume / Issue: 19 (10) Sequence Number: - Start / End Page: 1901 - 1920 Identifier: ISSN: 1467-7644
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569611