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  Contributions of the international plant science community to the fight against infectious diseases in humans – part 2: affordable drugs in edible plants for endemic and re-emerging diseases

He, W., Baysal, C., Lobato Gómez, M., Huang, X., Alvarez, D., Zhu, C., et al. (2021). Contributions of the international plant science community to the fight against infectious diseases in humans – part 2: affordable drugs in edible plants for endemic and re-emerging diseases. Plant Biotechnology Journal, 19(10), 1921-1936. doi:10.1111/pbi.13658.

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Genre: Journal Article
Alternative Title : Plant Biotechnology Journal

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 Creators:
He, Wenshu1, Author
Baysal, Can1, Author
Lobato Gómez, Maria1, Author
Huang, Xin1, Author
Alvarez, Derry1, Author
Zhu, Changfu1, Author
Armario-Najera, Victoria1, Author
Blanco Perera, Aamaya1, Author
Cerda Bennaser, Pedro1, Author
Saba-Mayoral, Andrea1, Author
Sobrino-Mengual, Guillermo1, Author
Vargheese, Ashwin1, Author
Abranches, Rita1, Author
Abreu, Isabel Alexandra1, Author
Balamurugan, Shanmugaraj1, Author
Bock, R.2, Author              
Buyel, Johannes F.1, Author
Cunha, Nicolau B. da1, Author
Daniell, Henry1, Author
Faller, Roland1, Author
Folgado, André1, AuthorGowtham, Iyappan1, AuthorHäkkinen, Suvi T.1, AuthorShashi, Kumar1, AuthorRamalingam, Sathish Kumar1, AuthorLacorte, Cristiano1, AuthorLomonossoff, George P.1, AuthorLuís, Ines M.1, AuthorK.-C. Ma, Julian1, AuthorMcDonald, Karen A.1, AuthorMurad, Andre1, AuthorNandi, Somen1, AuthorO’Keef, Barry1, AuthorParthiban, Subramanian1, AuthorPaul, Mathew J.1, AuthorPonndorf, Daniel1, AuthorRech, Elibio1, AuthorRodrigues, Julio C.M.1, AuthorRuf, Stephanie1, AuthorSchillberg, S.1, AuthorSchwestka, Jennifer1, AuthorShah, Priya S.1, AuthorSingh, Rahul1, AuthorStoger, Eva1, AuthorTwyman, Richard M.1, AuthorVarghese, Inchakalody P.1, AuthorVianna, Giovanni R.1, AuthorWebster, Gina1, AuthorWilbers, Ruud H.P.1, AuthorChristou, Paul1, AuthorOksman-Caldentey, Kirsi-Marja1, AuthorCapell, Teresa1, Author more..
Affiliations:
1external, ou_persistent22              
2Organelle Biology and Biotechnology, Department Bock, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753326              

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Free keywords: Molecular farming, plant-made pharmaceuticals, oral delivery, endemic disease, re-emerging disease
 Abstract: Summary The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases, and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure, and that eliminate the need for expensive purification steps and sterile delivery by injection.

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Language(s): eng - English
 Dates: 2021-06-28
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/pbi.13658
 Degree: -

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Title: Plant Biotechnology Journal
  Other : Plant Biotechnol. J.
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Pub.
Pages: - Volume / Issue: 19 (10) Sequence Number: - Start / End Page: 1921 - 1936 Identifier: ISSN: 1467-7644
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569611