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  Genome-wide association studies: assessing trait characteristics in model and crop plants

Alseekh, S., Kostova, D., Bulut, M., & Fernie, A. R. (2021). Genome-wide association studies: assessing trait characteristics in model and crop plants. Cellular and Molecular Life Sciences, 78(15), 5743-5754. doi:10.1007/s00018-021-03868-w.

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 Creators:
Alseekh, S.1, Author           
Kostova, Dimitrina2, Author
Bulut, M.1, Author           
Fernie, A. R.3, Author           
Affiliations:
1The Genetics of Crop Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_3244836              
2external, ou_persistent22              
3Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              

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 Abstract: GWAS involves testing genetic variants across the genomes of many individuals of a population to identify genotype–phenotype association. It was initially developed and has proven highly successful in human disease genetics. In plants genome-wide association studies (GWAS) initially focused on single feature polymorphism and recombination and linkage disequilibrium but has now been embraced by a plethora of different disciplines with several thousand studies being published in model and crop species within the last decade or so. Here we will provide a comprehensive review of these studies providing cases studies on biotic resistance, abiotic tolerance, yield associated traits, and metabolic composition. We also detail current strategies of candidate gene validation as well as the functional study of haplotypes. Furthermore, we provide a critical evaluation of the GWAS strategy and its alternatives as well as future perspectives that are emerging with the emergence of pan-genomic datasets.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1007/s00018-021-03868-w
Other: Alseekh2021
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Title: Cellular and Molecular Life Sciences
Source Genre: Journal
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Publ. Info: Basel : Birkhaeuser Verlag
Pages: - Volume / Issue: 78 (15) Sequence Number: - Start / End Page: 5743 - 5754 Identifier: ISSN: 1420-682X
CoNE: https://pure.mpg.de/cone/journals/resource/954926942730