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  Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy

Song, M., Scheifele, M., Barthel, H., van Eimeren, T., Beyer, L., Marek, K., et al. (2021). Feasibility of short imaging protocols for [18F]PI-2620 tau-PET in progressive supranuclear palsy. European Journal of Nuclear Medicine and Molecular Imaging. doi:10.1007/s00259-021-05391-3.

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 Creators:
Song, Mengmeng, Author
Scheifele, Maximilian, Author
Barthel, Henryk, Author
van Eimeren, Thilo, Author
Beyer, Leonie, Author
Marek, Ken, Author
Eckenweber, Florian, Author
Palleis, Carla, Author
Kaiser, Lena, Author
Finze, Anika, Author
Kern, Maike, Author
Nitschmann, Alexander, Author
Biechele, Gloria, Author
Katzdobler, Sabrina, Author
Bischof, Gèrard, Author
Hammes, Jochen, Author
Jessen, Frank, Author
Saur, Dorothee, Author
Schroeter, Matthias L.1, Author              
Rumpf, Jost-Julian, Author
Rullmann, Michael, AuthorSchildan, Andreas, AuthorPatt, Marianne, AuthorNeumaier, Bernd, AuthorStephens, Andrew W., AuthorRauchmann, Boris-Stephan, AuthorPerneczky, Robert, AuthorLevin, Johannes, AuthorClassen, Joseph, AuthorHöglinger, Günter U., AuthorBartenstein, Peter, AuthorBoening, Guido, AuthorZiegler, Sibylle, AuthorVillemagne, Victor, AuthorDrzezga, Alexander, AuthorSeibyl, John, AuthorSabri, Osama, AuthorBrendel, Matthias, AuthorGerman Imaging Initiative for Tauopathies (GII4T), Author               more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Progressive supranuclear palsy; Tau-PET; Time window; [18F]PI-2620
 Abstract: Purpose: Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [18F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [18F]PI-2620 tau-PET imaging of PSP. Methods: Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [18F]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 min p.i.. All DVR and SUVr data were compared with regard to their potential to discriminate patients with PSP-RS from HCs in predefined subcortical and cortical target regions (effect size, area under the curve (AUC), multi-region classifier). Results: 0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%. Conclusion: Truncated and static imaging windows can be used for [18F]PI-2620 PET imaging of PSP. 0-40 min dynamic scanning offers the best balance between accuracy and economic scanning.

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Language(s): eng - English
 Dates: 2021-01-242021-04-262021-05-22
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s00259-021-05391-3
Other: online ahead or print
PMID: 34021393
 Degree: -

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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624