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  Toward deep biophysical cytometry: prospects and challenges

Lee, K. C., Guck, J., Goda, K., & Tsia, K. K. (2021). Toward deep biophysical cytometry: prospects and challenges. Trends in Biotechnology, 39(12), 1249-1262. doi:10.1016/j.tibtech.2021.03.006.

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 Creators:
Lee, Kelvin C.M.1, Author
Guck, Jochen2, 3, 4, Author           
Goda, Keisuke1, Author
Tsia, Kevin K.1, Author
Affiliations:
1external, ou_persistent22              
2Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
3Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              
4Friedrich-Alexander-Universität Erlangen-Nürnberg, Department Physik, ou_persistent22              

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 Abstract: The biophysical properties of cells reflect their identities, underpin their homeostatic
state in health, and define the pathogenesis of disease. Recent leapfrogging
advances in biophysical cytometry now give access to this information,
which is obscured in molecular assays, with a discriminative power that was
once inconceivable. However, biophysical cytometry should go 'deeper' in
terms of exploiting the information-rich cellular biophysical content, generating
a molecular knowledge base of cellular biophysical properties, and standardizing
the protocols for wider dissemination. Overcoming these barriers, which
requires concurrent innovations in microfluidics, optical imaging, and computer
vision, could unleash the enormous potential of biophysical cytometry not only
for gaining a new mechanistic understanding of biological systems but also for
identifying new cost-effective biomarkers of disease.

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Language(s): eng - English
 Dates: 2021-04-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tibtech.2021.03.006
 Degree: -

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Title: Trends in Biotechnology
Source Genre: Journal
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Publ. Info: Cell Press
Pages: - Volume / Issue: 39 (12) Sequence Number: - Start / End Page: 1249 - 1262 Identifier: ISSN: 1879-3096