English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Activation and inhibition of the calcium gate of sarcoplasmic reticulum by high-affinity ryanodine binding

Hasselbach, W., & Migala, A. (1987). Activation and inhibition of the calcium gate of sarcoplasmic reticulum by high-affinity ryanodine binding. FEBS Letters, 221(1), 119-123. doi:10.1016/0014-5793(87)80364-2.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0008-D93E-F Version Permalink: https://hdl.handle.net/21.11116/0000-0008-D93F-E
Genre: Journal Article

Files

show Files
hide Files
:
FEBSLett_221_1987_119.pdf (Any fulltext), 403KB
 
File Permalink:
-
Name:
FEBSLett_221_1987_119.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Locator:
https://febs.onlinelibrary.wiley.com/doi/epdf/10.1016/0014-5793%2887%2980364-2 (Any fulltext)
Description:
-
OA-Status:
Locator:
https://doi.org/10.1016/0014-5793(87)80364-2 (Any fulltext)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Hasselbach, Wilhelm1, Author           
Migala, Andrea1, Author           
Affiliations:
1Department of Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_3321127              

Content

show
hide
Free keywords: -
 Abstract: The occupancy of high-affinity ryanodine-binding sites of isolated heavy sarcoplasmic reticulum vesicles occurring in concentrated salt solutions affects ATP-dependent calcium accumulation and caffeine-induced calcium release. The initial suppression of calcium uptake is followed by a marked uptake activation resulting in a reduction of the final calcium level in the medium. Simultaneously, caffeine-induced calcium release is blocked. The dependence of inhibition of calcium uptake and caffeine-induced calcium release observed in assay media containing physiological concentrations of magnesium and ATP on the concentration of ryanodine corresponds to the drug's effectiveness in living muscles.

Details

show
hide
Language(s): eng - English
 Dates: 1987-07-101987-08-31
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0014-5793(87)80364-2
URI: https://pubmed.ncbi.nlm.nih.gov/3622757/
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: FEBS Letters
  Other : FEBS Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 221 (1) Sequence Number: - Start / End Page: 119 - 123 Identifier: ISSN: 0014-5793
CoNE: https://pure.mpg.de/cone/journals/resource/954925399501