Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of 
Experimental Cholangiocarcinoma.

Colyn, Leticia; Bárcena-Varela, Marina; Álvarez-Sola, Gloria; Latasa, M Ujue; Uriarte, Iker; Santamaría, Eva; Herranz, Jose M; Santos-Laso, Alvaro; Arechederra, Maria; Gauna, Mikel Ruiz de; Aspichueta, Patricia; Canale, Matteo; Casadei-Gardini, Andrea; Francesconi, Maria; Carotti, Simone; Morini, Sergio; Nelson, Leonard J; Iraburu, Maria J; Chen, Chaobo; Sangro, Bruno; Marin, Jose Jg; Martinez-Chantar, Maria L; Banales, Jesus M; Arnes-Benito, Robert; Huch, Meritxell; Patino, John; Dar, Altaf A; Nosrati, Mehdi; Oyarzábal, Julen; Prósper, Felipe; Urman, Jesus; Cubero, Francisco Javier; Trautwein, Christian; Berasain, Carmen; Fernandez-Barrena, Maite G; Avila, Matias A

doi:10.1002/hep.31642

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Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.

Colyn, L., Bárcena-Varela, M., Álvarez-Sola, G., Latasa, M. U., Uriarte, I., Santamaría, E., et al. (2021). Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma. Hepatology (Baltimore, Md.), 73(6), 2380-2396. doi:10.1002/hep.31642.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-DA98-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0008-DA99-6

Genre: Journal Article

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Creators:
Colyn, Leticia, Author
Bárcena-Varela, Marina, Author
Álvarez-Sola, Gloria, Author
Latasa, M Ujue, Author
Uriarte, Iker, Author
Santamaría, Eva, Author
Herranz, Jose M, Author
Santos-Laso, Alvaro, Author
Arechederra, Maria, Author
Gauna, Mikel Ruiz de, Author
Aspichueta, Patricia, Author
Canale, Matteo, Author
Casadei-Gardini, Andrea, Author
Francesconi, Maria, Author
Carotti, Simone, Author
Morini, Sergio, Author
Nelson, Leonard J, Author
Iraburu, Maria J, Author
Chen, Chaobo, Author
Sangro, Bruno, Author
Marin, Jose Jg, AuthorMartinez-Chantar, Maria L, AuthorBanales, Jesus M, AuthorArnes-Benito, Robert, AuthorHuch, Meritxell¹, Author Patino, John, AuthorDar, Altaf A, AuthorNosrati, Mehdi, AuthorOyarzábal, Julen, AuthorPrósper, Felipe, AuthorUrman, Jesus, AuthorCubero, Francisco Javier, AuthorTrautwein, Christian, AuthorBerasain, Carmen, AuthorFernandez-Barrena, Maite G, AuthorAvila, Matias A, Author more..

Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692

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Abstract: Cholangiocarcinoma (CCA) is a devastating disease often detected at advanced stages when surgery cannot be performed. Conventional and targeted systemic therapies perform poorly, and therefore effective drugs are urgently needed. Different epigenetic modifications occur in CCA and contribute to malignancy. Targeting epigenetic mechanisms may thus open therapeutic opportunities. However, modifications such as DNA and histone methylation often coexist and cooperate in carcinogenesis. We tested the therapeutic efficacy and mechanism of action of a class of dual G9a histone-methyltransferase and DNA-methyltransferase 1 (DNMT1) inhibitors.

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Dates: Date issued: 2021-06-01

Publication Status: Issued

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Identifiers: DOI: 10.1002/hep.31642
Other: cbg-7852
PMID: 33222246

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Title: Hepatology (Baltimore, Md.)

Other : Hepatology

Source Genre: Journal

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Pages: - Volume / Issue: 73 (6) Sequence Number: - Start / End Page: 2380 - 2396 Identifier: -