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  Differentiable model-based adaptive optics for two-photon microscopy

Vishniakou, I., & Seelig, J. D. (2021). Differentiable model-based adaptive optics for two-photon microscopy. Optics Express, 29(14), 21418-21427. doi:10.1364/OE.424344.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-DD3E-B Version Permalink: https://hdl.handle.net/21.11116/0000-000C-1186-9
Genre: Journal Article

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oe-29-14-21418.pdf (Publisher version), 5MB
 
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2021
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© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement ; OSA Open Access License for OSA-Formatted Journal Article PDFs: An OSA-formatted open access journal article PDF may be governed by the OSA Open Access Publishing Agreement signed by the author and any applicable copyright laws. Authors and readers may use, reuse, and build upon the article, or use it for text or data mining without asking prior permission from the publisher or the Author(s), as long as the purpose is non-commercial and appropriate attribution is maintained.
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https://www.osapublishing.org/oe/fulltext.cfm?uri=oe-29-14-21418&id=452707 (Publisher version)
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https://arxiv.org/abs/2104.14308 (Preprint)
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 Creators:
Vishniakou, Ivan1, Author           
Seelig, Johannes D.1, Author                 
Affiliations:
1Max Planck Research Group Neural Circuits, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_2237639              

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 Abstract: Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be combined with the optimization techniques of machine learning frameworks to find aberration corrections, as was demonstrated for focusing a laser beam through aberrations onto a camera [Opt. Express 2826436 (26436) [CrossRef] ]. Here, we extend this approach to two-photon scanning microscopy. The developed sensorless technique finds corrections for aberrations in scattering samples and will be useful for a range of imaging application, for example in brain tissue.

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Language(s): eng - English
 Dates: 2021-06-23
 Publication Status: Published online
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 Rev. Type: Peer
 Identifiers: DOI: 10.1364/OE.424344
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Title: Optics Express
  Abbreviation : Opt Express
Source Genre: Journal
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Publ. Info: Washington, DC : Optical Society of America
Pages: - Volume / Issue: 29 (14) Sequence Number: - Start / End Page: 21418 - 21427 Identifier: ISSN: 1094-4087
CoNE: https://pure.mpg.de/cone/journals/resource/954925609918