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  The organizational principles of de-differentiated topographic maps in somatosensory cortex

Liu, P., Chrysidou, A., Doehler, J., Hebart, M. N., Wolbers, T., & Kuehn, E. (2021). The organizational principles of de-differentiated topographic maps in somatosensory cortex. eLife, 10: e60090. doi:10.7554/eLife.60090.

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 Creators:
Liu, Peng1, 2, Author
Chrysidou, Anastasia1, 2, Author
Doehler, Juliane1, 2, Author
Hebart, Martin N.3, Author           
Wolbers, Thomas2, 4, Author
Kuehn, Esther1, 2, 4, Author
Affiliations:
1Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2German Center for Neurodegenerative Diseases, Magdeburg, ou_persistent22              
3Max Planck Research Group Vision and Computational Cognition, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3158378              
4Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              

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Free keywords: 7 Tesla MRI; Aging; Human; Neuroscience; pRF mapping; Somatosensation; Somatotopy; Touch
 Abstract: Topographic maps are a fundamental feature of cortex architecture in the mammalian brain. One common theory is that the de-differentiation of topographic maps links to impairments in everyday behavior due to less precise functional map readouts. Here, we tested this theory by characterizing de-differentiated topographic maps in primary somatosensory cortex (SI) of younger and older adults by means of ultra-high resolution functional magnetic resonance imaging together with perceptual finger individuation and hand motor performance. Older adults' SI maps showed similar amplitude and size to younger adults' maps, but presented with less representational similarity between distant fingers. Larger population receptive field sizes in older adults' maps did not correlate with behavior, whereas reduced cortical distances between D2 and D3 related to worse finger individuation but better motor performance. Our data uncover the drawbacks of a simple de-differentiation model of topographic map function, and motivate the introduction of feature-based models of cortical reorganization.

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Language(s): eng - English
 Dates: 2021-05-18
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.60090
PMID: 34003108
PMC: PMC8186903
 Degree: -

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Project name : -
Grant ID : ZS/2016/04/78113
Funding program : -
Funding organization : Center for Behavioral Brain Sciences
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Grant ID : KU 3711/2-1
Funding program : (423633679)
Funding organization : German Research Foundation
Project name : -
Grant ID : 2019-A03
Funding program : -
Funding organization : Else Kröner-Fresenius-Stiftung

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 10 Sequence Number: e60090 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X