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Free keywords:
Functional connectivity; Large-scale network; Subthalamic nucleus; Thalamus; Basal ganglia; Deep brain stimulation; fMRI; Resting state; Motor task
Abstract:
The exact mechanisms of the central effects of deep brain stimulation (DBS) are still unknown. With the development of MR-compatible DBS systems, there are new opportunities to explore their impact on the functioning of local and remote networks using fMRI at rest or when performing various tasks. Current knowledge comes mainly from DBS of the subthalamic nucleus (STN)—the most common target in Parkinson’s disease. While initial studies on effective STN DBS reported changes mainly in local activity patterns, later studies described changes in large-scale networks, and the results are only partially consistent with the classical basal ganglia model. Previously published results still suffer from great variability and a low number of subjects. However, the goals are ambitious. Initial results suggest that fMRI may help select suitable patients for DBS, predict future effects, set optimal stimulation parameters, or even search for new promising targets.
