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Introduction Determining potential risk factors of amyloid beta (A beta) misfolding in blood, a risk marker for clinical Alzheimer's disease (AD), could have important implications for its utility in future research and clinical settings.
Methods Participants aged 50 to 75 years attending a general health examination were recruited for a prospective community-based cohort study in Saarland, Germany, in 2000 to 2002. For these analyses, participants with available A beta misfolding measurements and clinical AD information at 17-year follow-up were included (n = 444).
Results Age did not show any association with A beta misfolding in plasma; however, a strong association of both age and A beta misfolding with the incidence of clinical AD was evident. Education and cardiovascular diseases were likewise not associated with A beta misfolding.
Discussion Structural measurement of A beta misfolding in blood plasma is an age-independent risk marker of clinical AD among older adults, supporting that risk of clinical AD is already largely determined before older adulthood.
