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  Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

Ostkamp, P., Salmen, A., Pignolet, B., Goerlich, D., Andlauer, T. M. F., Schulte-Mecklenbeck, A., et al. (2021). Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(1): e2018457118. doi:10.1073/pnas.2018457118.

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Ostkamp, Patrick, Autor
Salmen, Anke, Autor
Pignolet, Beatrice, Autor
Goerlich, Dennis, Autor
Andlauer, Till M. F.1, Autor           
Schulte-Mecklenbeck, Andreas, Autor
Gonzalez-Escamilla, Gabriel, Autor
Bucciarelli, Florence, Autor
Gennero, Isabelle, Autor
Breuer, Johanna, Autor
Antony, Gisela, Autor
Schneider-Hohendorf, Tilman, Autor
Mykicki, Nadine, Autor
Bayas, Antonios, Autor
Bergh, Florian Then, Autor
Bittner, Stefan, Autor
Hartung, Hans-Peter, Autor
Friese, Manuel A., Autor
Linker, Ralf A., Autor
Luessi, Felix, Autor
Lehmann-Horn, Klaus, AutorMuehlau, Mark, AutorPaul, Friedemann, AutorStangel, Martin, AutorTackenberg, Bjorn, AutorTumani, Hayrettin, AutorWarnke, Clemens, AutorWeber, Frank, AutorWildemann, Brigitte, AutorZettl, Uwe K., AutorZiemann, Ulf, AutorMuller-Myhsok, Bertram2, Autor           Kuempfel, Tania, AutorKlotz, Luisa, AutorMeuth, Sven G., AutorZipp, Frauke, AutorHemmer, Bernhard, AutorHohlfeld, Reinhard, AutorBrassat, David, AutorGold, Ralf, AutorGross, Catharina C., AutorLukas, Carsten, AutorGroppa, Sergiu, AutorLoser, Karin, AutorWiendl, Heinz, AutorSchwab, Nicholas, Autor mehr..
Affiliations:
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2RG Statistical Genetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040288              

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 Zusammenfassung: Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-beta-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests benefidal effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.

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 Datum: 2021
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: ISI: 000607270100058
DOI: 10.1073/pnas.2018457118
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Titel: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 118 (1) Artikelnummer: e2018457118 Start- / Endseite: - Identifikator: ISSN: 0027-8424