Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Delta 9-tetrahydrocannabinol-exposed rats

Di Bartolomeo, M., Stark, T., Maurel, O. M., Iannotti, F. A., Kuchar, M., Ruda-Kucerova, J., et al. (2021). Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Delta 9-tetrahydrocannabinol-exposed rats. PHARMACOLOGICAL RESEARCH, 164: 105357. doi:10.1016/j.phrs.2020.105357.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Di Bartolomeo, Martina, Autor
Stark, Tibor1, Autor           
Maurel, Oriana Maria2, Autor           
Iannotti, Fabio Arturo, Autor
Kuchar, Martin, Autor
Ruda-Kucerova, Jana, Autor
Piscitelli, Fabiana, Autor
Laudani, Samuele, Autor
Pekarik, Vladimir, Autor
Salomone, Salvatore, Autor
Arosio, Beatrice, Autor
Mechoulam, Raphael, Autor
Maccarrone, Mauro, Autor
Drago, Filippo, Autor
Wotjak, Carsten T.2, Autor           
Di Marzo, Vincenzo, Autor
Vismara, Matteo, Autor
Dell'Osso, Bernardo, Autor
D'Addario, Claudio, Autor
Micale, Vincenzo, Autor
Affiliations:
1Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035294              
2RG Neuronal Plasticity, Dept. Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Max Planck Society, ou_2040295              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Perinatal exposure to Delta(9)-tetrahydrocannabinol (THC) affects brain development and might increase the incidence of psychopathology later in life, which seems to be related to a dysregulation of endocannabinoid and/or dopaminergic systems. We here evaluated the transcriptional regulation of the genes encoding for the cannabinoid CB1 receptor (Cnr1) and the dopamine D2 receptor (Drd2) in perinatal THC-(pTHC) exposed male rats, focusing on the role of DNA methylation analyzed by pyrosequencing. Simultaneously, the molecular and behavioral abnormalities at two different time points (i.e., neonatal age and adulthood) and the potential preventive effect of peripubertal treatment with cannabidiol, a non-euphoric component of Cannabis, were assessed. The DRD2 methylation was also evaluated in a cohort of subjects with schizophrenia. We observed an increase in both Cnr1 and Drd2 mRNA levels selectively in the prefrontal cortex of adult pTHC-exposed rats with a consistent reduction in DNA methylation at the Drd2 regulatory region, paralleled by social withdrawal and cognitive impairment which were reversed by cannabidiol treatment. These adult abnormalities were preceded at neonatal age by delayed appearance of neonatal reflexes, higher Drd2 mRNA and lower 2-arachidonoylglycerol (2-AG) brain levels, which persisted till adulthood. Alterations of the epigenetic mark for DRD2 were also found in subjects with schizophrenia. Overall, reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2021
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000615153300017
DOI: 10.1016/j.phrs.2020.105357
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: PHARMACOLOGICAL RESEARCH
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 164 Artikelnummer: 105357 Start- / Endseite: - Identifikator: ISSN: 1043-6618