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  Variability in infants' functional brain network connectivity is associated with differences in affect and behavior

Kelsey, C. M., Farris, K., & Grossmann, T. (2021). Variability in infants' functional brain network connectivity is associated with differences in affect and behavior. Frontiers in Psychiatry, 12: 685754. doi:10.3389/fpsyt.2021.685754.

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 Creators:
Kelsey, Caroline M.1, 2, Author
Farris, Katrina2, 3, Author
Grossmann, Tobias2, 4, Author           
Affiliations:
1Division of Developmental Medicine, Department of Pediatrics, Boston Children's Hospital, MA, USA, ou_persistent22              
2Department of Psychology, University of Virginia, Charlottesville, VA, USA, ou_persistent22              
3University of Virginia, Neuroscience Institute, Georgia State University, Atlanta, GA, USA, ou_persistent22              
4Max Planck Research Group Early Social Development, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356545              

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Free keywords: Functional near infrared spectroscopy; Functional connectivity; Default mode network; Fronto parietal network; Infancy; Temperament
 Abstract: Variability in functional brain network connectivity has been linked to individual differences in cognitive, affective, and behavioral traits in adults. However, little is known about the developmental origins of such brain-behavior correlations. The current study examined functional brain network connectivity and its link to behavioral temperament in typically developing newborn and 1-month-old infants (M [age] = 25 days; N = 75) using functional near-infrared spectroscopy (fNIRS). Specifically, we measured long-range connectivity between cortical regions approximating fronto-parietal, default mode, and homologous-interhemispheric networks. Our results show that connectivity in these functional brain networks varies across infants and maps onto individual differences in behavioral temperament. Specifically, connectivity in the fronto-parietal network was positively associated with regulation and orienting behaviors, whereas connectivity in the default mode network showed the opposite effect on these behaviors. Our analysis also revealed a significant positive association between the homologous-interhemispheric network and infants' negative affect. The current results suggest that variability in long-range intra-hemispheric and cross-hemispheric functional connectivity between frontal, parietal, and temporal cortex is associated with individual differences in affect and behavior. These findings shed new light on the brain origins of individual differences in early-emerging behavioral traits and thus represent a viable novel approach for investigating developmental trajectories in typical and atypical neurodevelopment.

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Language(s): eng - English
 Dates: 2021-03-252021-05-142021-06-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fpsyt.2021.685754
Other: eCollection 2021
PMID: 34177669
PMC: PMC8220897
 Degree: -

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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 12 Sequence Number: 685754 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640