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  Adaptation of spontaneous activity in the developing visual cortex

Wosniack, M. E., Kirchner, J. H., Chao, L.-Y., Zabouri, N., Lohmann, C., & Gjorgjieva, J. (2021). Adaptation of spontaneous activity in the developing visual cortex. eLife, (10): e61619. doi:10.7554/eLife.61619.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-E93D-E Version Permalink: https://hdl.handle.net/21.11116/0000-0008-E93E-D
Genre: Journal Article

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https://pubmed.ncbi.nlm.nih.gov/33722342/ (Any fulltext)
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 Creators:
Wosniack, Marina E.1, 2, Author
Kirchner, Jan H.1, 2, Author
Chao, Ling-Ya1, Author
Zabouri, Nawal3, Author
Lohmann, Christian3, 4, Author
Gjorgjieva, Julijana1, Author           
Affiliations:
1Computation in Neural Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461694              
2School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany, ou_persistent22              
3Netherlands Institute for Neuroscience, Amsterdam, Netherlands, ou_persistent22              
4Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, Netherlands, ou_persistent22              

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Free keywords: adaptation; development; mouse; neuroscience; spontaneous activity; synaptic plasticity; visual cortex
 Abstract: Spontaneous activity drives the establishment of appropriate connectivity in different circuits during brain development. In the mouse primary visual cortex, two distinct patterns of spontaneous activity occur before vision onset: local low-synchronicity events originating in the retina and global high-synchronicity events originating in the cortex. We sought to determine the contribution of these activity patterns to jointly organize network connectivity through different activity-dependent plasticity rules. We postulated that local events shape cortical input selectivity and topography, while global events homeostatically regulate connection strength. However, to generate robust selectivity, we found that global events should adapt their amplitude to the history of preceding cortical activation. We confirmed this prediction by analyzing in vivo spontaneous cortical activity. The predicted adaptation leads to the sparsification of spontaneous activity on a slower timescale during development, demonstrating the remarkable capacity of the developing sensory cortex to acquire sensitivity to visual inputs after eye-opening.

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Language(s): eng - English
 Dates: 2020-07-302021-02-032021-03-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.61619
 Degree: -

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Project name : -
Grant ID : -
Funding program : Capes-Humboldt Postdoctoral Research Fellowship
Funding organization : Alexander von Humboldt-Stiftung
Project name : ERC-2018-STG NeuroDevo
Grant ID : 804824
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)
Project name : -
Grant ID : 26253
Funding program : NARSAD Young Investigator Grant
Funding organization : Brain and Behavior Research Foundation
Project name : -
Grant ID : -
Funding program : SMART START training program in computational neuroscience
Funding organization : -

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: (10) Sequence Number: e61619 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X