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  Kybernetische Untersuchungen zur Strahlenwirkung auf Hefezellen - II. Induktion von Lagzeiten und Entwicklung von Riesenzellen nach Röntgenbestrahlung / Cybernetic studies on the radiation effects on yeast cells. II. Induction of lagtime and development of giant cells following roentgen irradiation

Pohlit, W., & Domke, A. (1966). Kybernetische Untersuchungen zur Strahlenwirkung auf Hefezellen - II. Induktion von Lagzeiten und Entwicklung von Riesenzellen nach Röntgenbestrahlung / Cybernetic studies on the radiation effects on yeast cells. II. Induction of lagtime and development of giant cells following roentgen irradiation. Biophysik, 3(2), 140-147. doi:10.1007/BF01191607.

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 Creators:
Pohlit, Wolfgang1, Author           
Domke, A.1, Author           
Affiliations:
1Max Planck Institute of Biophysics, Max Planck Society, ou_2068288              

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 Abstract: After X-irradiation two different types of yeast cells can be observed. The so-called n-cells, which cannot grow to macrocolonies, are produced by a typical “yes-no”-reaction. Their further fate (giant cells) is independent of the applied absorbed dose. The other kind of cells, the so-called m-cells, can grow to macrocolonies. They show after X-irradiation an induced lag time t0lag. The curvature of the proliferation curve during the lagtime t1lag is a measure for the spread of the population of m-cells. The normal spread of yeast cells is present also after X-irradiation, indicating that all m-cells of the population got a radiation damage of the same magnitude. This radiation effect is not a “yes-no”-reaction since the length of the induced lagtime t0lag is dose dependent. Diploide and haploide yeast cells show the same general behaviour. Nevertheless the sensitivity for the induced lagtime t0lag is within a factor of about two higher in haploide cells. This indicates differences between those strains due to reactions, which can be regulated by the cell after irradiation.
Nach Röntgenbestrahlung von Saccharomyces Zellen entstehen im wesentlichen zwei Zelltypen (m- und n-Zellen), deren Schicksale direkt nach Bestrahlungsende quantitativ verfolgt werden. n-Zellen werden durch eine Reaktion vomjanein-Typ erzeugt, ihr weiteres Schicksal (Aufwachsen zu Riesenzellen) ist praktisch dosisunabhängig. Diem-Zellen zeigen nach Bestrahlung eine Lagzeit, deren Länge dosisabhängig ist. Haploide Zellen verhalten sich ebenso wie diploide Zellen; für die Induktion der Lagzeit beim-Zellen sind haploide Zellen um einen Faktor zwei strahlenempfindlicher. Ein kybernetisches Modell zur Beschreibung dieser Ergebnisse wird in einer folgenden Arbeit gegeben.

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Language(s): deu - German
 Dates: 1966-01-101966-06-01
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1007/BF01191607
PMID: 5982792
 Degree: -

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Title: Biophysik
  Other : Radiation and Environmental Biophysics
  Abbreviation : Radiat. Environ. Biophys.
Source Genre: Journal
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Publ. Info: Berlin : Springer-Verlag
Pages: - Volume / Issue: 3 (2) Sequence Number: - Start / End Page: 140 - 147 Identifier: ISSN: 0301-634X
CoNE: https://pure.mpg.de/cone/journals/resource/954925510402