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Abstract:
Whole-brain data were acquired using a non-accelerated, non-lipid-suppressed and ultra-short echo time 1H FID-MRSI 2D multi-slice sequence at 9.4 T on human subjects. Data was reconstructed, retrospectively lipid suppressed and fitted including a relaxation corrected macromolecular basis spectrum. Metabolite concentration maps showing expected concentration differences between gray and white matter could be achieved with 89-97% coverage of the whole brain for tCr, tCho, NAA, Glu, and mI. A stack of 32 mm thickness covering the central part of the cerebrum yields anatomically correct maps for Gln, Tau, GABA, NAAG, and GSH. The data acquisition and reconstruction lead to reproducible results.
