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  Glycoproteomics Technologies in Glycobiotechnology

Alagesan, K., Hoffmann, M., Rapp, E., & Kolarich, D. (2020). Glycoproteomics Technologies in Glycobiotechnology. In Advances in Biochemical Engineering/Biotechnology. doi:10.1007/10_2020_144.

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 Creators:
Alagesan, Kathirvel1, Author
Hoffmann, Marcus, Author
Rapp, Erdmann, Author
Kolarich, Daniel, Author
Affiliations:
1Max Planck Unit for the Science of Pathogens, Max Planck Society, ou_3213696              

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Free keywords: Mass spectrometry, Biopharmaceuticals, Analytics, Glycoproteomics
 Abstract: Glycosylation is a key factor determining the pharmacological properties of biotherapeutics, including their stability, solubility, bioavailability, pharmacokinetics, and immunogenicity. As such, comprehensive information about glycosylation of biotherapeutics is critical to demonstrate similarity. Regulatory agencies also require extensive documentation of the comprehensive analyses of glycosylation-related critical quality attributes (CQAs) during the development, manufacturing, and release of biosimilars. Mass spectrometry has catalysed tremendous advancements in the characterisation of glycosylation CQAs of biotherapeutics. Here we provide a perspective overview on the MS-based technologies relevant for biotherapeutic product characterisation with an emphasis on the recent developments that allow determination of glycosylation features such as site of glycosylation, sialic acid linkage, glycan structure, and content.Graphical AbstractOpen image in new window

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 Dates: 2020
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/10_2020_144
BibTex Citekey: alagesan_glycoproteomics_nodate
 Degree: -

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Title: Advances in Biochemical Engineering/Biotechnology
Source Genre: Series
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Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: -

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Title: Advances in Glycobiotechnology
Source Genre: Book
 Creator(s):
Rapp, E., Editor
Reichl, U., Editor
Affiliations:
-
Publ. Info: Springer, Cham, 1
Pages: 463 Volume / Issue: 175 Sequence Number: - Start / End Page: 413 - 434 Identifier: -