English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells

van der Weijden, V., & Bulut-Karslioglu, A. (2021). Molecular Regulation of Paused Pluripotency in Early Mammalian Embryos and Stem Cells. Frontiers in Cell and Developmental Biology, 9: 9:708318. doi:10.3389/fcell.2021.708318.

Item is

Basic

show hide
Genre: Review Article

Files

show Files
hide Files
:
van der Weijden_2021.pdf (Publisher version), 2MB
Name:
van der Weijden_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2021 van der Weijden and Bulut-Karslioglu

Locators

show

Creators

show
hide
 Creators:
van der Weijden, Vera1, Author              
Bulut-Karslioglu, Aydan1, Author              
Affiliations:
1Stem Cell Chromatin (Aydan Bulut-Karslioglu), Dept. of Genome Regulation, (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3014185              

Content

show
hide
Free keywords: embryonic diapause, pluripotency, dormancy, metabolism, transcription, miRNA, signaling pathways, stem cells
 Abstract: The energetically costly mammalian investment in gestation and lactation requires plentiful nutritional sources and thus links the environmental conditions to reproductive success. Flexibility in adjusting developmental timing enhances chances of survival in adverse conditions. Over 130 mammalian species can reversibly pause early embryonic development by switching to a near dormant state that can be sustained for months, a phenomenon called embryonic diapause. Lineage-specific cells are retained during diapause, and they proliferate and differentiate upon activation. Studying diapause thus reveals principles of pluripotency and dormancy and is not only relevant for development, but also for regeneration and cancer. In this review, we focus on the molecular regulation of diapause in early mammalian embryos and relate it to maintenance of potency in stem cells in vitro. Diapause is established and maintained by active rewiring of the embryonic metabolome, epigenome, and gene expression in communication with maternal tissues. Herein, we particularly discuss factors required at distinct stages of diapause to induce, maintain, and terminate dormancy.

Details

show
hide
Language(s): eng - English
 Dates: 2021-07-062021-07-27
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fcell.2021.708318
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Frontiers in Cell and Developmental Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Frontiers Media
Pages: - Volume / Issue: 9 Sequence Number: 9:708318 Start / End Page: - Identifier: Other: 2296-634X
CoNE: https://pure.mpg.de/cone/journals/resource/2296-634X