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  A thalamocortical top-down circuit for associative memory

Pardi, M. B., Vogenstahl, J., Dalmay, T., Spanò, T., Pu, D.-L., Naumann, L. B., et al. (2020). A thalamocortical top-down circuit for associative memory. Science, 370(6518), 844-848. doi:10.1126/science.abc2399.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0008-F959-C Version Permalink: https://hdl.handle.net/21.11116/0000-0008-F95A-B
Genre: Journal Article

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https://pubmed.ncbi.nlm.nih.gov/33184213/ (Any fulltext)
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 Creators:
Pardi, M. Belén1, Author
Vogenstahl, Johanna1, Author
Dalmay, Tamas1, 2, Author
Spanò, Teresa1, 3, Author
Pu, De-Lin1, Author
Naumann, Laura B4, 5, Author
Kretschmer, Friedrich1, Author
Sprekeler, Henning4, 5, Author
Letzkus, J.J.1, 6, Author           
Affiliations:
1Neocortical Circuits Group, Max Planck Institute for Brain Research, Max Planck Society, ou_2461700              
2Donders Centre for Neuroscience, Faculty of Science, Radboud University, 6525 AJ Nijmegen, Netherlands, ou_persistent22              
3Faculty of Biological Sciences, Goethe Universität Frankfurt, 60438 Frankfurt, Germany, ou_persistent22              
4Bernstein Center for Computational Neuroscience Berlin, 10115 Berlin, Germany, ou_persistent22              
5Department of Electrical Engineering and Computer Science, Technische Universität Berlin, 10587 Berlin, Germany, ou_persistent22              
6Institute for Physiology I, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany, ou_persistent22              

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 Abstract: The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are tightly and dynamically controlled by local presynaptic inhibition. Our results not only identify the higher-order thalamus as a highly plastic source of cortical top-down information but also reveal a level of computational flexibility in layer 1 that goes far beyond hard-wired connectivity.

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Language(s): eng - English
 Dates: 2020-04-142020-09-302020-11-13
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/science.abc2399
 Degree: -

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Project name : SPP 1665
Grant ID : 322093917
Funding program : Schwerpunktprogramme
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : SFB 1193
Grant ID : 264810226
Funding program : Sonderforschungsbereiche
Funding organization : Deutsche Forschungsgemeinschaft (DFG)
Project name : AttentionCircuits
Grant ID : 335587
Funding program : Funding Programme 7 (FP7)
Funding organization : European Commission (EC)
Project name : -
Grant ID : -
Funding program : Long Term Fellowship
Funding organization : Human Frontier Science Program

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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 370 (6518) Sequence Number: - Start / End Page: 844 - 848 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1