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  Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome

Neumann, A., Meinke, S., Goldammer, G., Strauch, M., Schubert, D., Timmermann, B., et al. (2020). Alternative splicing coupled mRNA decay shapes the temperature‐dependent transcriptome. EMBO Reports, 21(12): e51369. doi:10.15252/embr.202051369.

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 Creators:
Neumann, Alexander, Author
Meinke, Stefan , Author
Goldammer, Gesine , Author
Strauch, Miriam , Author
Schubert, Daniel , Author
Timmermann, Bernd1, Author           
Heyd, Florian , Author
Preußner, Marco , Author
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1Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

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Free keywords: alternative splicing; circadian clock; mRNA decay; NMD; SRproteins; temperature
 Abstract: Mammalian body temperature oscillates with the time of the dayand is altered in diverse pathological conditions. We recently iden-tified a body temperature-sensitive thermometer-like kinase,which alters SR protein phosphorylation and thereby globallycontrols alternative splicing (AS). AS can generate unproductivevariants which are recognized and degraded by diverse mRNAdecay pathways—including nonsense-mediated decay (NMD). Herewe show extensive coupling of body temperature-controlled AS tomRNA decay, leading to global control of temperature-dependentgene expression (GE). Temperature-controlled, decay-inducingsplicing events are evolutionarily conserved and pervasively foundwithin RNA-binding proteins, including most SR proteins. AS-coupledpoison exon inclusion is essential for rhythmic GE of SR proteins andhas a global role in establishing temperature-dependent rhythmicGE profiles, both in mammals under circadian body temperaturecycles and in plants in response to ambient temperature changes.Together, these data identify body temperature-driven AS-coupledmRNA decay as an evolutionary ancient, core clock-independentmechanism to generate rhythmic GE.

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Language(s): eng - English
 Dates: 2020-10-082020-11-022020-12-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.15252/embr.202051369
 Degree: -

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Title: EMBO Reports
  Other : EMBO Rep.
Source Genre: Journal
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Publ. Info: Oxford, UK : Published for EMBO by Oxford University Press
Pages: - Volume / Issue: 21 (12) Sequence Number: e51369 Start / End Page: - Identifier: ISSN: 1469-221X
CoNE: https://pure.mpg.de/cone/journals/resource/110978984569661