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  Longitudinal changes of spinal cord grey and white matter following spinal cord injury

David, G., Pfyffer, D., Vallotton, K., Pfender, N., Thompson, A., Weiskopf, N., et al. (2021). Longitudinal changes of spinal cord grey and white matter following spinal cord injury. Journal of Neurology, Neurosurgery & Psychiatry, 92(11), 1222-1230. doi:10.1136/jnnp-2021-326337.

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 Creators:
David, Gergely1, Author
Pfyffer, Dario1, Author
Vallotton, Kevin1, Author
Pfender, Nikolai1, Author
Thompson, Alan2, Author
Weiskopf, Nikolaus3, 4, Author           
Mohammadi, Siawoosh3, 5, Author           
Curt, Armin1, Author
Freund, Patrick1, 2, 3, 6, Author           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland, ou_persistent22              
2Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
6Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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 Abstract: Objectives: Traumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and white matter neurodegeneration above and below the injury is understudied. Methods: We acquired longitudinal data from 13 traumatic and 3 non-traumatic spinal cord injury patients (8-8 cervical and thoracic cord injuries) within 1.5 years after injury and 10 healthy controls over the same period. The protocol encompassed structural and diffusion-weighted MRI rostral (C2/C3) and caudal (lumbar enlargement) to the injury level to track tissue-specific neurodegeneration. Regression models assessed group differences in the temporal evolution of tissue-specific changes and associations with clinical outcomes. Results: At 2 months post-injury, white matter area was decreased by 8.5% and grey matter by 15.9% in the lumbar enlargement, while at C2/C3 only white matter was decreased (-9.7%). Patients had decreased cervical fractional anisotropy (FA: -11.3%) and increased radial diffusivity (+20.5%) in the dorsal column, while FA was lower in the lateral (-10.3%) and ventral columns (-9.7%) of the lumbar enlargement. White matter decreased by 0.34% and 0.35% per month at C2/C3 and lumbar enlargement, respectively, and grey matter decreased at C2/C3 by 0.70% per month. Conclusions: This study describes the spatiotemporal dynamics of tissue-specific spinal cord neurodegeneration above and below a spinal cord injury. While above the injury, grey matter atrophy lagged initially behind white matter neurodegeneration, in the lumbar enlargement these processes progressed in parallel. Tracking trajectories of tissue-specific neurodegeneration provides valuable assessment tools for monitoring recovery and treatment effects.

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Language(s): eng - English
 Dates: 2021-08-022021-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1136/jnnp-2021-326337
Other: epub 2021
PMID: 34341143
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Project name : -
Grant ID : WFL-CH-007/14
Funding program : -
Funding organization : Wings for Life
Project name : -
Grant ID : IRP-P158 and IRP-P184
Funding program : -
Funding organization : International Foundation for Research in Paraplegia
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union
Project name : -
Grant ID : 01EW1711A and B
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Funding organization : Bundesministerium für Bildung und Forschung
Project name : -
Grant ID : PCEFP3_181362/1
Funding program : -
Funding organization : SNF Eccellenza Professorial Fellowship
Project name : -
Grant ID : 616905
Funding program : -
Funding organization : European Research Counsil
Project name : -
Grant ID : MO 2397/4-1
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft
Project name : -
Grant ID : 091593/Z/10/Z
Funding program : -
Funding organization : Wellcome Trust

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Title: Journal of Neurology, Neurosurgery & Psychiatry
Source Genre: Journal
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Pages: - Volume / Issue: 92 (11) Sequence Number: - Start / End Page: 1222 - 1230 Identifier: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000