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  Longitudinal changes of spinal cord grey and white matter following spinal cord injury

David, G., Pfyffer, D., Vallotton, K., Pfender, N., Thompson, A., Weiskopf, N., et al. (2021). Longitudinal changes of spinal cord grey and white matter following spinal cord injury. Journal of Neurology, Neurosurgery & Psychiatry, 92(11), 1222-1230. doi:10.1136/jnnp-2021-326337.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-1CA7-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-000D-4E6C-4
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 Urheber:
David, Gergely1, Autor
Pfyffer, Dario1, Autor
Vallotton, Kevin1, Autor
Pfender, Nikolai1, Autor
Thompson, Alan2, Autor
Weiskopf, Nikolaus3, 4, Autor           
Mohammadi, Siawoosh3, 5, Autor           
Curt, Armin1, Autor
Freund, Patrick1, 2, 3, 6, Autor           
Affiliations:
1Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zürich, Switzerland, ou_persistent22              
2Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
4Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
5Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
6Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              

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 Zusammenfassung: Objectives: Traumatic and non-traumatic spinal cord injury produce neurodegeneration across the entire neuraxis. However, the spatiotemporal dynamics of spinal cord grey and white matter neurodegeneration above and below the injury is understudied.

Methods: We acquired longitudinal data from 13 traumatic and 3 non-traumatic spinal cord injury patients (8-8 cervical and thoracic cord injuries) within 1.5 years after injury and 10 healthy controls over the same period. The protocol encompassed structural and diffusion-weighted MRI rostral (C2/C3) and caudal (lumbar enlargement) to the injury level to track tissue-specific neurodegeneration. Regression models assessed group differences in the temporal evolution of tissue-specific changes and associations with clinical outcomes.

Results: At 2 months post-injury, white matter area was decreased by 8.5% and grey matter by 15.9% in the lumbar enlargement, while at C2/C3 only white matter was decreased (-9.7%). Patients had decreased cervical fractional anisotropy (FA: -11.3%) and increased radial diffusivity (+20.5%) in the dorsal column, while FA was lower in the lateral (-10.3%) and ventral columns (-9.7%) of the lumbar enlargement. White matter decreased by 0.34% and 0.35% per month at C2/C3 and lumbar enlargement, respectively, and grey matter decreased at C2/C3 by 0.70% per month.

Conclusions: This study describes the spatiotemporal dynamics of tissue-specific spinal cord neurodegeneration above and below a spinal cord injury. While above the injury, grey matter atrophy lagged initially behind white matter neurodegeneration, in the lumbar enlargement these processes progressed in parallel. Tracking trajectories of tissue-specific neurodegeneration provides valuable assessment tools for monitoring recovery and treatment effects.

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Sprache(n): eng - English
 Datum: 2021-08-022021-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1136/jnnp-2021-326337
Anderer: epub 2021
PMID: 34341143
 Art des Abschluß: -

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Projektinformation

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Projektname : -
Grant ID : WFL-CH-007/14
Förderprogramm : -
Förderorganisation : Wings for Life
Projektname : -
Grant ID : IRP-P158 and IRP-P184
Förderprogramm : -
Förderorganisation : International Foundation for Research in Paraplegia
Projektname : -
Grant ID : 681094
Förderprogramm : Horizon 2020
Förderorganisation : European Union
Projektname : -
Grant ID : 01EW1711A and B
Förderprogramm : -
Förderorganisation : Bundesministerium für Bildung und Forschung (BMBF)
Projektname : -
Grant ID : PCEFP3_181362/1
Förderprogramm : -
Förderorganisation : SNF Eccellenza Professorial Fellowship
Projektname : -
Grant ID : 616905
Förderprogramm : -
Förderorganisation : European Research Council (ERC)
Projektname : -
Grant ID : MO 2397/4-1
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : -
Grant ID : 091593/Z/10/Z
Förderprogramm : -
Förderorganisation : Wellcome Trust

Quelle 1

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Titel: Journal of Neurology, Neurosurgery & Psychiatry
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 92 (11) Artikelnummer: - Start- / Endseite: 1222 - 1230 Identifikator: ISSN: 0022-3050
CoNE: https://pure.mpg.de/cone/journals/resource/111085522793000