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  Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis

Huang, T.-W., Iyer, A. A., Manalo, J. M., Woo, J., Bosquez Huerta, N. A., McGovern, M. M., et al. (2021). Glial-Specific Deletion of Med12 Results in Rapid Hearing Loss via Degradation of the Stria Vascularis. The Journal of Neuroscience. doi:10.1523/JNEUROSCI.0070-21.2021.

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Huang_2021_accepted manuscript.pdf (Preprint), 10MB
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Huang, Teng-Wei, Author
Iyer, Amrita A. , Author
Manalo, Jeanne M. , Author
Woo, Junsung, Author
Bosquez Huerta, Navish A., Author
McGovern, Melissa M. , Author
Schrewe, Heinrich1, Author           
Pereira, Fredrick A. , Author
Groves, Andrew K. , Author
Ohlemiller, Kevin K. , Author
Deneen, Benjamin , Author
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1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              

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 Abstract: Mediator protein complex subunit 12 (Med12) is a core component of the basal transcriptional apparatus and plays a critical role in the development of many tissues. Mutations in Med12 are associated with X-linked intellectual disability syndromes and hearing loss; however, its role in nervous system function remains undefined. Here, we show that temporal conditional deletion of Med12 in astrocytes in the adult central nervous system results in region specific alterations in astrocyte morphology. Surprisingly, behavioral studies revealed rapid hearing loss after adult deletion of Med12 that was confirmed by a complete abrogation of auditory brainstem responses. Cellular analysis of the cochlea revealed degeneration of the stria vascularis, in conjunction with disorganization of basal cells adjacent to the spiral ligament and downregulation of key cell adhesion proteins. Physiological analysis revealed early changes in endocochlear potential, consistent with strial-specific defects. Together, our studies reveal that Med12 regulates auditory function in the adult by preserving the structural integrity of the stria vascularis.

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Language(s): eng - English
 Dates: 2021-07-052021-07-12
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.0070-21.2021
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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1