English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Nuclear speckles: dynamic hubs of gene expression regulation

Ilik, I. A., & Aktas, T. (2021). Nuclear speckles: dynamic hubs of gene expression regulation. The FEBS Journal. doi:10.1111/febs.16117.

Item is

Basic

show hide
Genre: Review Article

Files

show Files
hide Files
:
Ilik_2021.pdf (Publisher version), 2MB
Name:
Ilik_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
© 2021 The Authors

Locators

show

Creators

show
hide
 Creators:
Ilik, Ibrahim Avsar1, Author              
Aktas, Tugce1, Author              
Affiliations:
1Quantitative RNA Biology (Tugce Aktas), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_3014184              

Content

show
hide
Free keywords: nuclear speckles; phase separation; SON; splicing; SRRM2; transcription
 Abstract: Complex, multistep biochemical reactions that routinely take place in our cells require high concentrations of enzymes, substrates, and other structural components to proceed efficiently and typically require chemical environments that can inhibit other reactions in their immediate vicinity. Eukaryotic cells solve these problems by restricting such reactions into diffusion-restricted compartments within the cell called organelles that can be separated from their environment by a lipid membrane, or into membrane-less compartments that form through liquid–liquid phase separation (LLPS). One of the most easily noticeable and the earliest discovered organelle is the nucleus, which harbors the genetic material in cells where transcription by RNA polymerases produces most of the messenger RNAs and a plethora of noncoding RNAs, which in turn are required for translation of mRNAs in the cytoplasm. The interior of the nucleus is not a uniform soup of biomolecules and rather consists of a variety of membrane-less bodies, such as the nucleolus, nuclear speckles (NS), paraspeckles, Cajal bodies, histone locus bodies, and more. In this review, we will focus on NS with an emphasis on recent developments including our own findings about the formation of NS by two large IDR-rich proteins SON and SRRM2.

Details

show
hide
Language(s): eng - English
 Dates: 2021-07-082021-07-10
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/febs.16117
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The FEBS Journal
  Other : The Federation if European Biochemical Societies Journal
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1742-464X
CoNE: https://pure.mpg.de/cone/journals/resource/954925398485