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  Cell competition in intratumoral and tumor microenvironment interactions

Parker, T. M., Gupta, K., Palma, A. M., Yekelchyk, M., Fisher, P. B., Grossman, S. R., et al. (2021). Cell competition in intratumoral and tumor microenvironment interactions. EMBO JOURNAL, e107271. doi:10.15252/embj.2020107271.

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 Creators:
Parker, Taylor M., Author
Gupta, Kartik, Author
Palma, Antonio M., Author
Yekelchyk, Michail1, Author           
Fisher, Paul B., Author
Grossman, Steven R., Author
Won, Kyoung Jae, Author
Madan, Esha, Author
Moreno, Eduardo, Author
Gogna, Rajan, Author
Affiliations:
1Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society, ou_2591695              

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Free keywords: CLONAL EVOLUTION; HIPPO PATHWAY; MYC; CANCER; ELIMINATION; SELECTION; HETEROGENEITY; ACTIVATION; NEIGHBORS; DRIVENBiochemistry & Molecular Biology; Cell Biology; cancer; cell competition; chemotherapy; clonal selection; tumor heterogeneity;
 Abstract: Tumors are complex cellular and acellular environments within which cancer clones are under continuous selection pressures. Cancer cells are in a permanent mode of interaction and competition with each other as well as with the immediate microenvironment. In the course of these competitive interactions, cells share information regarding their general state of fitness, with less-fit cells being typically eliminated via apoptosis at the hands of those cells with greater cellular fitness. Competitive interactions involving exchange of cell fitness information have implications for tumor growth, metastasis, and therapy outcomes. Recent research has highlighted sophisticated pathways such as Flower, Hippo, Myc, and p53 signaling, which are employed by cancer cells and the surrounding microenvironment cells to achieve their evolutionary goals by means of cell competition mechanisms. In this review, we discuss these recent findings and explain their importance and role in evolution, growth, and treatment of cancer. We further consider potential physiological conditions, such as hypoxia and chemotherapy, that can function as selective pressures under which cell competition mechanisms may evolve differently or synergistically to confer oncogenic advantages to cancer.

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Language(s): eng - English
 Dates: 2021-08-09
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000682923200001
DOI: 10.15252/embj.2020107271
PMID: 34368984
 Degree: -

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Title: EMBO JOURNAL
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Pages: - Volume / Issue: - Sequence Number: e107271 Start / End Page: - Identifier: ISSN: 0261-4189