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  Generic acquisition protocol for quantitative MRI of the spinal cord

Cohen-Adad, J., Alonso-Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., et al. (2021). Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols, 16(10), 4611-4632. doi:10.1038/s41596-021-00588-0.

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Cohen-Adad, Julien1, Author
Alonso-Ortiz, Eva1, Author
Abramovic, Mihael1, Author
Arneitz, Carina1, Author
Atcheson, Nicole1, Author
Barlow, Laura1, Author
Barry, Robert L.1, Author
Barth, Markus1, Author
Battiston, Marco1, Author
Büchel, Christian1, Author
Budde, Matthew1, Author
Callot, Virginie1, Author
Combes, Anna J. E.1, Author
De Leener, Benjamin1, Author
Descoteaux, Maxime1, Author
de Sousa, Paulo Loureiro1, Author
Dostál, Marek1, Author
Doyon, Julien1, Author
Dvorak, Adam1, Author
Eippert, Falk2, Author           
Epperson, Karla R.1, AuthorEpperson, Kevin S.1, AuthorFreund, Patrick3, Author           Finsterbusch, Jürgen1, AuthorFoias, Alexandru1, AuthorFratini, Michela1, AuthorFukunaga, Issei1, AuthorWheeler-Kingshott, Claudia A. M. Gandini1, AuthorGermani, Giancarlo1, AuthorGilbert, Guillaume1, AuthorGiove, Federico1, AuthorGros, Charley1, AuthorGrussu, Francesco1, AuthorHagiwara, Akifumi1, AuthorHenry, Pierre-Gilles1, AuthorHorák, Tomáš1, AuthorHori, Masaaki1, AuthorJoers, James1, AuthorKamiya, Kouhei1, AuthorKarbasforoushan, Haleh1, AuthorKeřkovský, Miloš1, AuthorKhatibi, Ali1, AuthorKim, Joo-Won1, AuthorKinany, Nawal1, AuthorKitzler, Hagen1, AuthorKolind, Shannon1, AuthorKong, Yazhuo1, AuthorKudlička, Petr1, AuthorKuntke, Paul1, AuthorKurniawan, Nyoman D.1, AuthorKusmia, Slawomir1, AuthorLabounek, René1, AuthorLaganà, Maria Marcella1, AuthorLaule, Cornelia1, AuthorLaw, Christine S.1, AuthorLenglet, Christophe1, AuthorLeutritz, Tobias3, Author           Liu, Yaou1, AuthorLlufriu, Sara1, AuthorMackey, Sean1, AuthorMartinez-Heras, Eloy1, AuthorMattera, Loan1, AuthorNestrasil, Igor1, AuthorO’Grady, Kristin P.1, AuthorPapinutto, Nico1, AuthorPapp, Daniel1, AuthorPareto, Deborah1, AuthorParrish, Todd B.1, AuthorPichiecchio, Anna1, AuthorPrados, Ferran1, AuthorRovira, Àlex1, AuthorRuitenberg, Marc J.1, AuthorSamson, Rebecca S.1, AuthorSavini, Giovanni1, AuthorSeif, Maryam1, AuthorSeifert, Alan C.1, AuthorSmith, Alex K.1, AuthorSmith, Seth A.1, AuthorSmith, Zachary A.1, AuthorSolana, Elisabeth1, AuthorSuzuki, Yuichi1, AuthorTackley, George1, AuthorTinnermann, Alexandra1, AuthorValošek, Jan1, AuthorVan De Ville, Dimitri1, AuthorYiannakas, Marios C.1, AuthorWeber, Kenneth A.1, AuthorWeiskopf, Nikolaus3, Author           Wise, Richard G.1, AuthorWyss, Patrik O.1, AuthorXu, Junqian1, Author more..
1External Organizations, ou_persistent22              
2Max Planck Research Group Pain Perception, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2497695              
3Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              


Free keywords: Imaging techniques; Spinal cord diseases
 Abstract: Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.


Language(s): eng - English
 Dates: 2020-10-202021-06-102021-08-162021-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41596-021-00588-0
Other: epub 2021
PMID: 34400839
 Degree: -



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Title: Nature Protocols
  Other : Nat. Protoc.
Source Genre: Journal
Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 16 (10) Sequence Number: - Start / End Page: 4611 - 4632 Identifier: ISSN: 1750-2799
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000223800_1